Wang Yan, Tang Liang, Pan Jiabao, Li Jianming, Zhang Qingsong, Chen Bifeng
Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, PR China; School of Basic Medical Science, Changsha Medical University, Changsha, PR China.
Department of Biological Science and Biotechnology, School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan, PR China.
Epilepsy Res. 2015 May;112:56-63. doi: 10.1016/j.eplepsyres.2015.02.007. Epub 2015 Feb 16.
ABCC2 gene polymorphisms have been shown to be associated with drug-resistant epilepsy. However, the published results were controversial. To comprehensively re-evaluate the association between ABCC2 gene polymorphisms and drug-resistant epilepsy in Asian, we carried out this meta-analysis, which included eight related studies. Studies were selected using PUBMED, Web of science, the Cochrane database of system reviews and Embase. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the association. Studies with 1302 drug-resistant cases and 1563 drug-sensitive controls were included. No significant association was detected by combined analyses for C-24T, G-1774delG, C3972T and G2934A. However, significant association was found in recessive model for G1249A polymorphism (GG vs. GA+AA: OR=0.72, 95%CI=0.53-0.96, P=0.03), indicating the recessive model of G1249A in MRP2/ABCC2 might decrease the risk of drug resistance in Asian epilepsy.
ABCC2基因多态性已被证明与耐药性癫痫有关。然而，已发表的结果存在争议。为了全面重新评估亚洲人群中ABCC2基因多态性与耐药性癫痫之间的关联，我们进行了这项荟萃分析，其中包括八项相关研究。研究通过PUBMED、科学网、Cochrane系统评价数据库和Embase进行筛选。采用合并比值比（OR）和95%置信区间（CI）来评估这种关联。纳入了1302例耐药病例和1563例药物敏感对照的研究。对C-24T、G-1774delG、C3972T和G2934A进行联合分析时未发现显著关联。然而，在G1249A多态性的隐性模型中发现了显著关联（GG与GA+AA相比：OR=0.72，95%CI=0.53-0.96，P=0.03），表明MRP2/ABCC2中G1249A的隐性模型可能会降低亚洲癫痫患者的耐药风险。
