Yang Xiaoqin, Wang Guiping, Wang Yaodong, Yue Xia
Department of Bioinformatics, School of Life Science and Technology, Tongji University, Shanghai, People's Republic of China.
Department of Pharmacy, College of Health Sciences, Guangzhou Medical University, People's Republic of China.
Neuropsychiatr Dis Treat. 2015 Mar 25;11:823-33. doi: 10.2147/NDT.S77966. eCollection 2015.
To date, the role of metabotropic glutamate receptor 3 (GRM3) rs274622, rs1468412, rs917071, rs6465084, and rs2299225 polymorphisms in schizophrenia remains controversial. To provide a clearer picture for the effect of the five most studied GRM3 polymorphisms on risk of schizophrenia, this meta-analysis with eligible data from published studies was performed. Relevant case-control studies were retrieved by literature search and selected according to established inclusion criteria. Odds ratios with 95% confidence intervals were used to assess the strength of association. A total of 33 individual studies were identified and included in our meta-analysis: nine for rs1468412, with 5,314 cases and 6,147 controls; six for rs917071, with 2,660 cases and 3,517 controls; seven for rs274622, with 3,820 cases and 4,015 controls; five for rs2299225, with 3,492 cases and 3,735 controls; and six for rs6465084, with 4,960 cases and 5,613 controls. However, no significant association was found between these GRM3 polymorphisms and schizophrenia in the overall population. With respect to rs1468412 polymorphism, a finding of very borderline statistical significance emerged in dominant comparison model for non-Asian populations, calling for large-scale verification to assess the marginally elevated risk of schizophrenia. In conclusion, these GRM3 polymorphisms have limited effect on the risks of schizophrenia. Further large and well-designed studies are needed to confirm this conclusion.
迄今为止，代谢型谷氨酸受体3（GRM3）基因的rs274622、rs1468412、rs917071、rs6465084和rs2299225多态性在精神分裂症中的作用仍存在争议。为了更清楚地了解这五个研究最多的GRM3多态性对精神分裂症风险的影响，我们对已发表研究中的合格数据进行了这项荟萃分析。通过文献检索获取相关病例对照研究，并根据既定的纳入标准进行筛选。采用95%置信区间的比值比来评估关联强度。共识别出33项个体研究并纳入我们的荟萃分析：rs1468412的研究有9项，病例5314例，对照6147例；rs917071的研究有6项，病例2660例，对照3517例；rs274622的研究有7项，病例3820例，对照4015例；rs2299225的研究有5项，病例3492例，对照3735例；rs6465084的研究有6项，病例4960例，对照5613例。然而，在总体人群中，这些GRM3多态性与精神分裂症之间未发现显著关联。对于rs1468412多态性，在非亚洲人群的显性比较模型中出现了非常接近统计学显著性的结果，需要大规模验证以评估精神分裂症略有升高的风险。总之，这些GRM3多态性对精神分裂症风险的影响有限。需要进一步开展大规模且设计良好的研究来证实这一结论。
