促性腺激素释放激素类似物对接受环磷酰胺治疗的大鼠卵巢储备的保护作用。

Protective effect of gonadotropin-releasing hormone analog on the ovarian reserve in rats receiving cyclophosphamide treatment.

作者信息

Gui Ting, Yuan Guangwen, Shen Keng, Cao Dongyan, Yang Jiaxin, Wu Ming, Lang Jinghe

机构信息

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, People's Republic of China.

Department of Gynecologic Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, People's Republic of China.

出版信息

Onco Targets Ther. 2015 Mar 23;8:661-7. doi: 10.2147/OTT.S78729. eCollection 2015.

DOI:10.2147/OTT.S78729

PMID:25848306

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4376258/

Abstract

OBJECTIVE

The aim of the study reported here was to investigate the protective effect of gonadotropin-releasing hormone analog (GnRHa) against cyclophosphamide (CTX)-induced gonadotoxicity.

METHODS

Eighty Fischer 344 rats were divided randomly into four groups (20 per group). One group received normal saline, one GnRHa, one CTX, and one GnRHa+CTX. Several parameters were used to observe the ovarian reserve, including ovary weight, follicle number and diameter, concentrations of estradiol (E2) and follicle-stimulating hormone (FSH), and expressions of sex hormone receptors.

RESULTS

When treatment was finished, the number of small follicles in the GnRHa+CTX group was significantly higher than in the CTX-alone group. Thirty days after treatment, the ovary weight, percentage of small follicles, mean follicular diameter, and serum concentrations of E2 and FSH in the GnRHa+CTX group all recovered, approaching normal levels. Sex hormone receptors did not show significant differences between the four groups.