O'Neil Edward B, Watson Hilary C, Dhillon Sonya, Lobaugh Nancy J, Lee Andy C H
University of Toronto, Ontario, Canada.
Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
J Cogn Neurosci. 2015 Sep;27(9):1708-22. doi: 10.1162/jocn_a_00816. Epub 2015 Apr 7.
Recent work has demonstrated that the perirhinal cortex (PRC) supports conjunctive object representations that aid object recognition memory following visual object interference. It is unclear, however, how these representations interact with other brain regions implicated in mnemonic retrieval and how congruent and incongruent interference influences the processing of targets and foils during object recognition. To address this, multivariate partial least squares was applied to fMRI data acquired during an interference match-to-sample task, in which participants made object or scene recognition judgments after object or scene interference. This revealed a pattern of activity sensitive to object recognition following congruent (i.e., object) interference that included PRC, prefrontal, and parietal regions. Moreover, functional connectivity analysis revealed a common pattern of PRC connectivity across interference and recognition conditions. Examination of eye movements during the same task in a separate study revealed that participants gazed more at targets than foils during correct object recognition decisions, regardless of interference congruency. By contrast, participants viewed foils more than targets for incorrect object memory judgments, but only after congruent interference. Our findings suggest that congruent interference makes object foils appear familiar and that a network of regions, including PRC, is recruited to overcome the effects of interference.
最近的研究表明，嗅周皮质（PRC）支持联合物体表征，这种表征在视觉物体干扰后有助于物体识别记忆。然而，尚不清楚这些表征如何与参与记忆检索的其他脑区相互作用，以及一致和不一致的干扰如何影响物体识别过程中目标和干扰物的处理。为了解决这个问题，多变量偏最小二乘法被应用于在干扰匹配样本任务中获取的功能磁共振成像（fMRI）数据，在该任务中，参与者在物体或场景干扰后进行物体或场景识别判断。这揭示了一种在一致（即物体）干扰后对物体识别敏感的活动模式，包括PRC、前额叶和顶叶区域。此外，功能连接分析揭示了PRC在干扰和识别条件下的连接的共同模式。在另一项研究中，对同一任务期间的眼动进行检查发现，在正确的物体识别决策过程中，无论干扰的一致性如何，参与者注视目标的时间都比干扰物长。相比之下，参与者在错误的物体记忆判断中注视干扰物的时间比目标长，但仅在一致干扰之后。我们的研究结果表明，一致干扰使物体干扰物看起来熟悉，并且包括PRC在内的一系列脑区被调动起来以克服干扰的影响。
