Nisarga R, Premalatha R, Ravikumar K L, Shivappa U, Gopi A, Chikkadasarahalli S B, Batuwanthudawe R, Kilgore P E, Kim S A, Balter I, Jouve S, Ye J, Moscariello M
Kempegowda Institute of Medical Sciences; Vani Vilas Hospital, Bangalore Medical College and Research Institute; Indira Gandhi Institute of Child Health, Bangalore, India; International Vaccine Institute, Seoul, Korea; Wayne State University, Detroit, MI, USA;Pfizer Inc, Paris, France; and Pfizer Inc, Collegeville, PA, USA. Correspondence to: Dr Ramalingowda Nisarga, Kempegowda Institute of Medical Sciences,. 121-13, T. Mariyappa Road, 1st Block, Jayanagara, Bangalore 560011, India.
Indian Pediatr. 2015 Mar 8;52(3):205-11. doi: 10.1007/s13312-015-0607-0.
To estimate the incidence of invasive pneumococcal disease and pneumonia, distribution of pneumococcal serotypes, and antibiotic susceptibility in children aged 28 days to <60 months.
Hospital-based surveillance.
South Bangalore, India.
9950 children aged 28 days to <60 months with clinical suspicion of invasive pneumococcal disease or pneumonia.
The estimated at-risk population included 224,966 children <5 years of age. Forty cases of invasive pneumococcal disease were identified. Estimated invasive pneumococcal disease incidence was 17.8/100,000 with incidence being highest among children aged 6 months to <12 months (49.9/100,000). Clinical pneumonia syndrome was the most frequent diagnosis (12.5/100,000). Pneumococcal serotypes included: 6A (n=6, 16.7%); 14 (n=5, 13.9%); 5 (n=4, 11.1%); 6B (n=4, 11.1%); 1, 18C, and 19A (n=3 each, 8.3%); 9V (n=2, 5.6%); and 3, 4, 10C, 18A, 18F, and 19F (n=1 each, 2.8%). Serotypes 6A, 14, 6B, 1, 18C, 19A, 9V, 4, 10C, and 18A showed antibiotic resistance. Clinical pneumonia incidence was 2109/100,000, with incidence being highest among children aged 28 days to <6 months (5033/100,000). Chest radiograph-confirmed pneumonia incidence was 1114/100,000, with incidence being highest among children aged 28 days to <6 months (2413/100,000).
Invasive pneumococcal disease and pneumonia were found to be common causes of morbidity in young children living in South Bangalore, India.
评估28天至不满60个月儿童侵袭性肺炎球菌病和肺炎的发病率、肺炎球菌血清型分布及抗生素敏感性。
基于医院的监测。
印度班加罗尔南部。
9950名28天至不满60个月、临床怀疑患有侵袭性肺炎球菌病或肺炎的儿童。
估计高危人群包括224,966名5岁以下儿童。共确诊40例侵袭性肺炎球菌病。估计侵袭性肺炎球菌病发病率为17.8/10万，其中6个月至不满12个月儿童发病率最高（49.9/10万）。临床肺炎综合征是最常见的诊断（12.5/10万）。肺炎球菌血清型包括：6A（n = 6，16.7%）；14（n = 5，13.9%）；5（n = 4，11.1%）；6B（n = 4，11.1%）；1、18C和19A（各n = 3，8.3%）；9V（n = 2，5.6%）；以及3、4、10C、18A、18F和19F（各n = 1，2.8%）。6A、14、6B、1、18C、19A、9V、4、10C和18A血清型显示有抗生素耐药性。临床肺炎发病率为2109/10万，其中28天至不满6个月儿童发病率最高（5033/10万）。胸部X线片确诊的肺炎发病率为1114/10万，其中28天至不满6个月儿童发病率最高（2413/10万）。
在印度班加罗尔南部的幼儿中，侵袭性肺炎球菌病和肺炎是常见的发病原因。
