BTNL2基因多态性与结节病易感性：一项荟萃分析。

BTNL2 gene polymorphism and sarcoidosis susceptibility: a meta-analysis.

作者信息

Lin Yihua, Wei Jia, Fan Lili, Cheng Deyun

机构信息

Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China; Department of Respiratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

出版信息

PLoS One. 2015 Apr 7;10(4):e0122639. doi: 10.1371/journal.pone.0122639. eCollection 2015.

BACKGROUND

Butyrophilin-like 2 (BTNL2) rs2076530 gene polymorphism has been implicated in susceptibility to sarcoidosis. However, results from previous studies are not consistent. To assess the association of BTNL2 polymorphism and sarcoidosis susceptibility, a meta-analysis was performed.

METHODS

PubMed, Embase were searched for eligible case-control studies. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated.

RESULTS

Ten studies involving a total of 3303 cases and 2514 controls were included in this meta-analysis. Combined data indicated that BTNL2 rs2076530 polymorphism was associated with sarcoidosis susceptibility in allelic model (A vs. G, OR = 1.59, 95%CI: 1.47-1.72), dominant model (AA + AG vs. GG, OR = 2.10, 95%CI: 1.67-2.65), and recessive model (AA vs. AG + GG, OR = 1.93, 95%CI: 1.49-2.50).

CONCLUSIONS

This meta-analysis indicates that BTNL2 rs2076530 polymorphism contributes to the risk of sarcoidosis.

背景

嗜乳脂蛋白样2（BTNL2）基因rs2076530多态性与结节病易感性有关。然而，先前研究的结果并不一致。为评估BTNL2多态性与结节病易感性之间的关联，进行了一项荟萃分析。

方法

检索PubMed、Embase数据库以查找符合条件的病例对照研究。提取数据并计算合并比值比（OR）及其95%置信区间（CI）。

结果

本荟萃分析纳入了10项研究，共3303例病例和2514例对照。合并数据表明，BTNL2基因rs2076530多态性在等位基因模型（A与G相比，OR = 1.59，95%CI：1.47 - 1.72）、显性模型（AA + AG与GG相比，OR = 2.10，95%CI：1.67 - 2.65）和隐性模型（AA与AG + GG相比，OR = 1.93，95%CI：1.49 - 2.50）中与结节病易感性相关。