以N,N-二甲基甲酰胺二甲醇缩醛为酮α-甲基化的碳源：烯胺酮的氢化-氢解策略
DMF Dimethyl Acetal as Carbon Source for α-Methylation of Ketones: A Hydrogenation-Hydrogenolysis Strategy of Enaminones.
作者信息
Borah Ashwini, Goswami Limi, Neog Kashmiri, Gogoi Pranjal
机构信息
Medicinal Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India.
出版信息
J Org Chem. 2015 May 1;80(9):4722-8. doi: 10.1021/acs.joc.5b00084. Epub 2015 Apr 20.
PMID:25849324
Abstract
A novel heterogeneous catalytic hydrogenation-hydrogenolysis strategy has been developed for the α-methylation of ketones via enaminones using DMF dimethyl acetal as carbon source. This strategy provides a very convenient route to α-methylated ketones using a variety of ketones without any base or oxidant.
摘要
已经开发出一种新型的多相催化氢化-氢解策略，用于通过烯胺酮以N,N-二甲基甲酰胺二甲醇缩醛作为碳源实现酮的α-甲基化。该策略为使用各种酮制备α-甲基化酮提供了一条非常便捷的途径，无需任何碱或氧化剂。
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