S-酰基转移酶的zDHHC家族。

The zDHHC family of S-acyltransferases.

作者信息

Lemonidis Kimon, Werno Martin W, Greaves Jennifer, Diez-Ardanuy Cinta, Sanchez-Perez Maria C, Salaun Christine, Thomson David M, Chamberlain Luke H

机构信息

*Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, U.K.

出版信息

Biochem Soc Trans. 2015 Apr;43(2):217-21. doi: 10.1042/BST20140270.

DOI:10.1042/BST20140270

PMID:25849920

Abstract

The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.

摘要

S-酰基转移酶zDHHC家族的发现是S-酰化领域的重大突破之一。如今，自它们被发现已过去十多年，主要问题集中在分析单个zDHHC酶的底物（有24个ZDHHC基因和数百种S-酰化蛋白）、确定酶-底物特异性的机制以及阐明该酶家族对细胞生理和病理的重要性。