Kouba Sana, Demaurex Nicolas
Department of Cell Physiology and Metabolism Centre Médical Universitaire, University of Geneva Geneva Switzerland.
Chronic Dis Transl Med. 2024 Aug 14;10(4):263-280. doi: 10.1002/cdt3.146. eCollection 2024 Dec.
Alterations in cellular calcium (Ca) signals have been causally associated with the development and progression of human cancers. Cellular Ca signals are generated by channels, pumps, and exchangers that move Ca ions across membranes and are decoded by effector proteins in the cytosol or in organelles. S-acylation, the reversible addition of 16-carbon fatty acids to proteins, modulates the activity of Ca transporters by altering their affinity for lipids, and enzymes mediating this reversible post-translational modification have also been linked to several types of cancers. Here, we compile studies reporting an association between Ca transporters or S-acylation enzymes with specific cancers, as well as studies reporting or predicting the S-acylation of Ca transporters. We then discuss the potential role of S-acylation in the oncogenic potential of a subset of Ca transport proteins involved in cancer.
细胞钙（Ca）信号的改变与人类癌症的发生和发展存在因果关系。细胞Ca信号由跨膜转运Ca离子的通道、泵和交换器产生，并由细胞质或细胞器中的效应蛋白进行解码。S-酰化是指将16碳脂肪酸可逆地添加到蛋白质上，通过改变Ca转运蛋白对脂质的亲和力来调节其活性，介导这种可逆翻译后修饰的酶也与几种类型的癌症有关。在这里，我们汇总了报告Ca转运蛋白或S-酰化酶与特定癌症之间关联的研究，以及报告或预测Ca转运蛋白S-酰化的研究。然后，我们讨论了S-酰化在参与癌症的一部分Ca转运蛋白的致癌潜力中的潜在作用。
