Messina Marco, Elalfy Mohamed, Ghoz Noha, Faraj Lana, Al-Aqaba Mouhamed, Dua Harminder S
Department of Ophthalmology, Nottingham University Hospitals, University of Nottingham, Nottingham, United Kingdom.
Cornea. 2015 Jun;34(6):707-9. doi: 10.1097/ICO.0000000000000430.
To report a case of calcified corneal nerves in an eye with long-standing diabetic eye disease.
This is a case report where the clinical diagnosis was made using a slit-lamp biomicroscope and confirmed using in vivo confocal microscopy. Photoslit-lamp images were taken for both eyes, and nerve thickness measurements made using ImageJ software.
A 70-year-old British white woman showed band keratopathy in the right eye and dense white lines and dots in her left cornea on slit-lamp examination. The left corneal images had an appearance exactly similar to stromal nerves and terminal bulbs reported before. In vivo confocal microscopy (IVCM) of the left cornea showed hyperreflective and thickened stromal and sub-Bowman nerves and their characteristic termination in bulbous thickenings.
Clinically detected corneal nerve calcification has not been described before. This report presents the direct visualization of calcified corneal nerves and their terminal bulbs and IVCM characteristics.
报告一例患有长期糖尿病眼病的眼睛出现角膜神经钙化的病例。
这是一例病例报告，通过裂隙灯生物显微镜进行临床诊断，并使用活体共聚焦显微镜进行确认。拍摄了双眼的裂隙灯照片，并使用ImageJ软件进行神经厚度测量。
一名70岁的英国白人女性在裂隙灯检查中右眼显示带状角膜病变，左眼角膜有密集的白色线条和小点。左眼角膜图像的外观与之前报道的基质神经和终球完全相似。左眼角膜的活体共聚焦显微镜检查（IVCM）显示基质和Bowman层下神经高反射且增厚，以及它们在球茎状增厚处的特征性终止。
临床上检测到的角膜神经钙化此前尚未有过描述。本报告展示了角膜神经钙化及其终球的直接可视化以及IVCM特征。
