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实施限制 39 孕周前计划性剖宫产政策后母婴结局:一项中断时间序列分析。

Maternal and neonatal outcomes after implementation of a hospital policy to limit low-risk planned caesarean deliveries before 39 weeks of gestation: an interrupted time-series analysis.

机构信息

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada.

Department of Epidemiology, Biostatistics and Occupational Health, Montréal, QC, Canada.

出版信息

BJOG. 2015 Aug;122(9):1200-6. doi: 10.1111/1471-0528.13396. Epub 2015 Apr 8.

DOI:10.1111/1471-0528.13396
PMID:25851865
Abstract

OBJECTIVE

To evaluate the extent to which implementing a hospital policy to limit planned caesarean deliveries before 39 weeks of gestation improved neonatal health, maternal health, and healthcare costs.

DESIGN

Retrospective cohort study.

SETTING

British Columbia Women's Hospital, Vancouver, Canada, in the period 2005-2012.

POPULATION

Women with a low-risk planned repeat caesarean delivery.

METHODS

An interrupted time series design was used to evaluate the policy to limit planned caesarean deliveries before 39 weeks of gestation, introduced on 1 April 2008.

MAIN OUTCOME MEASURES

Composite adverse neonatal health outcome (respiratory morbidity, 5-minute Apgar score of <7, neonatal intensive care unit admission, mortality), postpartum haemorrhage, obstetrical wound infection, out-of-hour deliveries, length of stay, and healthcare costs.

RESULTS

Between 2005 and 2008, 60% (1204/2021) of low-risk planned caesarean deliveries were performed before 39 weeks of gestation. After the introduction of the policy, the proportion of planned caesareans dropped by 20 percentage points (adjusted risk difference of 20 fewer cases per 100 deliveries; 95% CI -25.8, -14.3) to 41% (1033/2518). The policy had no detectable impact on adverse neonatal outcomes (2.2 excess cases per 100; 95% CI -0.4, 4.8), maternal complications, or healthcare costs, but increased the risk of out-of-hours delivery from 16.2 to 21.1% (adjusted risk difference 6.3 per 100; 95% CI 1.6, 10.9).

CONCLUSIONS

We found little evidence that a hospital policy to limit planned caesareans before 39 weeks of gestation reduced adverse neonatal outcomes. Hospital administrators intending to introduce such policies should anticipate, and plan for, modest increases in out-of-hours and emergency-timing.

摘要

目的

评估实施一项限制 39 周前计划性剖宫产的医院政策,对新生儿健康、产妇健康和医疗保健成本的影响程度。

设计

回顾性队列研究。

地点

加拿大温哥华不列颠哥伦比亚妇女医院,2005 年至 2012 年期间。

人群

低危计划再次剖宫产的妇女。

方法

采用中断时间序列设计,评估 2008 年 4 月 1 日实施的限制 39 周前计划性剖宫产的政策。

主要观察指标

复合不良新生儿健康结局(呼吸窘迫、5 分钟 Apgar 评分<7、新生儿重症监护病房入院、死亡)、产后出血、产科伤口感染、非工作时间分娩、住院时间和医疗保健成本。

结果

2005 年至 2008 年期间,60%(1204/2021)的低危计划剖宫产在 39 周前进行。政策实施后,计划性剖宫产的比例下降了 20 个百分点(调整风险差异为每 100 例分娩减少 20 例;95%CI-25.8,-14.3),降至 41%(1033/2518)。该政策对不良新生儿结局(每 100 例增加 2.2 例;95%CI-0.4,4.8)、产妇并发症或医疗保健成本均无明显影响,但增加了非工作时间分娩的风险,从 16.2%升至 21.1%(调整风险差异为每 100 例增加 6.3 例;95%CI1.6,10.9)。

结论

我们发现,限制 39 周前计划性剖宫产的医院政策几乎没有减少不良新生儿结局的证据。计划实施此类政策的医院管理人员应预料到并计划适度增加非工作时间和紧急情况下的分娩。

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