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Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels.

作者信息

Adekile Adekunle, Menzel Stephan, Gupta Renu, Al-Sharida Sondus, Farag Asma, Haider Mohammad, Akbulut Nagihan, Mustafa Nada, Thein Swee Lay

机构信息

Department of Pediatrics, Kuwait University, Kuwait City, Kuwait.

Faculty of Life Sciences & Medicine, , King's College London, London, United Kingdom.

出版信息

Am J Hematol. 2015 Jul;90(7):E138-9. doi: 10.1002/ajh.24027.

DOI:10.1002/ajh.24027
PMID:25851995
Abstract
摘要

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Response to hydroxyurea among Kuwaiti patients with sickle cell disease and elevated baseline HbF levels.科威特镰状细胞病患者且基线胎儿血红蛋白（HbF）水平升高者对羟基脲的反应。
Am J Hematol. 2015 Jul;90(7):E138-9. doi: 10.1002/ajh.24027.
2
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Chronic Administration of Hydroxyurea (HU) Benefits Caucasian Patients with Sickle-Beta Thalassemia.羟脲（HU）的慢性给药有益于患镰状细胞-β地中海贫血的白种人患者。
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Effects of hydroxyurea in a population of Brazilian patients with sickle cell anemia.羟基脲对巴西镰状细胞贫血患者群体的影响。
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Reduction of the clinical severity of sickle cell/beta-thalassemia with hydroxyurea: the experience of a single center in Greece.羟基脲降低镰状细胞/β地中海贫血的临床严重程度：希腊一家单中心的经验
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KLF10 gene expression is associated with high fetal hemoglobin levels and with response to hydroxyurea treatment in β-hemoglobinopathy patients.KLF10 基因表达与胎儿血红蛋白水平升高有关，并与β-地中海贫血病患者对羟基脲治疗的反应有关。
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[From Hemoglobin SS to SF: interest of hydroxyurea in the management of sickle cell disease in two Congolese children and review of the literature].[从血红蛋白SS到SF：羟基脲在两名刚果儿童镰状细胞病管理中的作用及文献综述]
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Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes.BABY HUG 队列中镰状细胞贫血的遗传修饰物：对实验室和临床表型的影响。
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Pharmacologic manipulation of fetal hemoglobin levels in sickle cell diseases and thalassemia: promise and reality.镰状细胞病和地中海贫血中胎儿血红蛋白水平的药物调控：前景与现实
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Sickle cell paths converge on hydroxyurea.镰状细胞病的研究方向都指向了羟基脲。
Nat Med. 1995 Apr;1(4):307-8. doi: 10.1038/nm0495-307.

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