Suntornsaratoon Panan, Krishnamra Nateetip, Charoenphandhu Narattaphol
Center of Calcium and Bone Research, Faculty of Science, Mahidol University, Bangkok, Thailand; and Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Center of Calcium and Bone Research, Faculty of Science, Mahidol University, Bangkok, Thailand; and Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
Am J Physiol Endocrinol Metab. 2015 Jun 1;308(11):E1010-22. doi: 10.1152/ajpendo.00049.2015. Epub 2015 Apr 7.
Adequate dietary calcium intake and the enhanced intestinal calcium absorption in lactating mothers have long been postulated to prevent maternal bone loss and benefit neonatal bone growth. We recently showed that calcium supplementation just before breastfeeding efficiently alleviated lactation-induced bone loss in dams as well as increased milk calcium concentration, which led to higher bone mineral density (BMD) in the newborns. Herein, we further elaborated in detail how presuckling calcium supplements worked in lactating rats and how they benefited bone growth in the offspring. As revealed by bone histomorphometry, presuckling supplement with calcium alone reduced the osteoclast surface and active erosion surface, leading to an increase in trabecular thickness without changes in trabecular separation or number in dams. The beneficial effects of presuckling calcium supplements, particularly the regimen containing glucose and galactose that enhanced intestinal calcium absorption, were found to last for 3 mo postweaning, although it could not restore estrogen-deficient osteopenia induced by ovariectomy. Regarding the neonatal benefits, pups nursed by calcium-supplemented dams exhibited increases in trabecular BMD, which could be observed even at the age of 27 wk. Bone elongation was also greater in pups of calcium-supplemented dams, which was due possibly to accelerated growth plate chondrocyte turnover. It could be concluded that calcium supplements markedly diminished the lactation-induced osteopenia in dams and positively affected BMD and bone elongation in growing rats. Therefore, presuckling calcium supplementation in lactating mothers is an effective strategy for promoting a long-lasting high bone density for both mother and the offspring.
长期以来，人们一直假定哺乳期母亲摄入足够的膳食钙并增强肠道对钙的吸收，可预防母体骨质流失，并有益于新生儿骨骼生长。我们最近发现，在哺乳前补充钙能有效减轻母鼠哺乳期骨质流失，并提高乳汁钙浓度，从而使新生鼠的骨矿物质密度（BMD）更高。在此，我们进一步详细阐述了哺乳前补充钙在哺乳期大鼠中的作用机制，以及它们如何有益于后代的骨骼生长。骨组织形态计量学结果显示，仅在哺乳前补充钙可减少破骨细胞表面和活性侵蚀表面，导致母鼠小梁厚度增加，而小梁间距或数量不变。我们发现，哺乳前补充钙的有益效果，特别是含有葡萄糖和半乳糖以增强肠道钙吸收的方案，在断奶后可持续3个月，尽管它无法恢复卵巢切除所致的雌激素缺乏性骨质减少。关于对新生儿的益处，由补充钙的母鼠哺育的幼崽小梁骨密度增加，甚至在27周龄时也能观察到。补充钙的母鼠所生幼崽的骨骼伸长也更大，这可能是由于生长板软骨细胞更新加速所致。可以得出结论，补充钙可显著减轻母鼠哺乳期骨质减少，并对生长中大鼠的骨密度和骨骼伸长产生积极影响。因此，哺乳期母亲在哺乳前补充钙是促进母亲和后代长期保持高骨密度的有效策略。
