Zhang Yuan-Qing, Guo Jin-Sheng
Yuan-Qing Zhang, Jin-Sheng Guo, Division of Digestive Diseases, Department of Internal Medicine, Zhong Shan Hospital, Shanghai Medical College, Fu Dan University, Shanghai 200032, China.
World J Gastroenterol. 2015 Apr 7;21(13):3860-6. doi: 10.3748/wjg.v21.i13.3860.
Chronic hepatitis B virus (HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma (HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments inhibit the replication of HBV, reduce serum viral load and accelerate hepatitis B e antigen serum conversion. Timely initiation of antiviral treatment is not only essential for preventing the incidence of HCC in chronic hepatitis B patients, but also important for reducing HBV reactivation, improving liver function, reducing or delaying HCC recurrence, and prolonging overall survival of HBV-related HCC patients after curative and palliative therapies. The selection of antiviral drugs, monitoring of indicators such as HBV DNA and hepatitis B surface antigen, and timely rescue treatment when necessary, are essential in antiviral therapies for HBV-related HCC.
慢性乙型肝炎病毒(HBV)感染是肝细胞癌(HCC)发生和进展的关键危险因素。它通过诱导肝纤维化、遗传和表观遗传改变以及活性病毒编码蛋白的表达来促进HCC的发展。有效的抗病毒治疗可抑制HBV复制、降低血清病毒载量并加速乙肝e抗原血清学转换。及时开始抗病毒治疗不仅对于预防慢性乙型肝炎患者发生HCC至关重要,而且对于减少HBV再激活、改善肝功能、减少或延迟HCC复发以及延长HBV相关HCC患者在根治性和姑息性治疗后的总生存期也很重要。抗病毒药物的选择、对HBV DNA和乙肝表面抗原等指标的监测以及必要时的及时挽救治疗,在HBV相关HCC的抗病毒治疗中至关重要。