Bang Chang Seok, Shin In Soo, Lee Sung Wha, Kim Jin Bong, Baik Gwang Ho, Suk Ki Tae, Yoon Jai Hoon, Kim Yeon Soo, Kim Dong Joon
Chang Seok Bang, Sung Wha Lee, Jin Bong Kim, Gwang Ho Baik, Ki Tae Suk, Jai Hoon Yoon, Yeon Soo Kim, Dong Joon Kim, Department of Internal Medicine, Hallym University College of Medicine, Chuncheon 200-704, South Korea.
World J Gastroenterol. 2015 Apr 7;21(13):4038-47. doi: 10.3748/wjg.v21.i13.4038.
To evaluate the association between alcoholic liver disease (ALD) and bone fractures or osteoporosis.
Non-randomized studies were identified from databases (PubMed, EMBASE, and the Cochrane Library). The search was conducted using Boolean operators and keywords, which included "alcoholic liver diseases", "osteoporosis", or "bone fractures". The prevalence of any fractures or osteoporosis, and bone mineral density (BMD) were extracted and analyzed using risk ratios and standardized mean difference (SMD). A random effects model was applied.
In total, 15 studies were identified and analyzed. Overall, ALD demonstrated a RR of 1.944 (95%CI: 1.354-2.791) for the development of bone fractures. However, ALD showed a RR of 0.849 (95%CI: 0.523-1.380) for the development of osteoporosis. BMD was not significantly different between the ALD and control groups, although there was a trend toward lower BMD in patients with ALD (SMD in femur-BMD: -0.172, 95%CI: -0.453-0.110; SMD in spine-BMD: -0.169, 95%CI: -0.476-0.138). Sensitivity analyses showed consistent results.
Current publications indicate significant associations between bone fractures and ALD, independent of BMD or the presence of osteoporosis.
评估酒精性肝病（ALD）与骨折或骨质疏松症之间的关联。
从数据库（PubMed、EMBASE和Cochrane图书馆）中检索非随机研究。使用布尔运算符和关键词进行检索，关键词包括“酒精性肝病”、“骨质疏松症”或“骨折”。提取任何骨折或骨质疏松症的患病率以及骨密度（BMD），并使用风险比和标准化均数差（SMD）进行分析。应用随机效应模型。
共识别并分析了15项研究。总体而言，ALD发生骨折的风险比为1.944（95%CI：1.354 - 2.791）。然而，ALD发生骨质疏松症的风险比为0.849（95%CI：0.523 - 1.380）。ALD组和对照组之间的骨密度无显著差异，尽管ALD患者的骨密度有降低趋势（股骨骨密度的SMD：-0.17２，95%CI：-0.453 - 0.110；脊柱骨密度的SMD：-0.169，95%CI：-0.476 - 0.138）。敏感性分析显示结果一致。
当前出版物表明骨折与ALD之间存在显著关联，与骨密度或骨质疏松症的存在无关。
