The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Department of Endocrinology, The First Hospital of Lan zhou University, Lanzhou, Gansu, China.
Osteoporos Int. 2022 Nov;33(11):2275-2286. doi: 10.1007/s00198-022-06459-y. Epub 2022 Jun 28.
UNLABELLED: The aim of this study was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and NAFLD. Patients with NAFLD should be monitored regularly for bone mineral density and bone metabolism indicators to prevent osteoporosis or osteoporotic fractures. OBJECTIVES: The aim of this meta-analysis was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and non-alcoholic fatty liver disease (NAFLD). METHODS: Five databases, including PubMed, Web of Science, Embase, Scopus and Cochrane Library, were searched since the conception of these databases until December 2021. The cohort studies, cross-sectional analyses or case-control studies evaluating the relationship between osteoporosis or osteoporotic fracture and NAFLD were retrieved from these databases. Relevant data were extracted from the included studies, and a meta-analysis was performed. RESULTS: A total of seven studies were included. The prevalence of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.17, 95%CI(1.04,1.31)], while the prevalence of osteoporosis was higher in the NAFLD group than in the non-NAFLD group [OR = 1.46, 95%CI (1.21,1.77) and OR = 1.48, 95%CI (1.31,1.68), respectively] in men and women. The risk of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.33,95%CI (1.24,1.44) and OR = 1.57,95%CI (1.08,2.29), respectively]. The risk of osteoporosis or osteoporotic fractures was higher in male and female NAFLD groups than that in the non-NAFLD group [OR = 1.29, 95%CI(1.14,1.47) and OR = 1.36, 95%CI (1.25,1.48), respectively]. After parameter adjustment, the risk of osteoporosis or osteoporotic fracture was higher in the male NAFLD group than in the non-NAFLD group [OR = 2.10, 95%CI(1.36,3.25)], while no significant difference was found among women [OR = 1.13, 95%CI (0.86,1.48)]. CONCLUSIONS: The prevalence and risk of osteoporosis or osteoporotic fractures were significantly associated with NAFLD in men and women. TRIAL REGISTRATION: PROSPERO 2022 CRD42022304708.
目的：本荟萃分析旨在探讨骨质疏松症或骨质疏松性骨折的患病率和风险与非酒精性脂肪性肝病（NAFLD）之间的关系。
方法：从各数据库建立起至 2021 年 12 月，检索了包括 PubMed、Web of Science、Embase、Scopus 和 Cochrane Library 在内的 5 个数据库，以获取评估骨质疏松症或骨质疏松性骨折与 NAFLD 之间关系的队列研究、横断面分析或病例对照研究。从纳入的研究中提取相关数据，并进行荟萃分析。
结果：共纳入 7 项研究。NAFLD 组的骨质疏松症或骨质疏松性骨折患病率高于非 NAFLD 组[OR=1.17，95%CI（1.04，1.31）]，而 NAFLD 组的骨质疏松症患病率高于非 NAFLD 组[OR=1.46，95%CI（1.21，1.77）和 OR=1.48，95%CI（1.31，1.68）]，无论男性还是女性。NAFLD 组的骨质疏松症或骨质疏松性骨折风险高于非 NAFLD 组[OR=1.33，95%CI（1.24，1.44）和 OR=1.57，95%CI（1.08，2.29）]。男性和女性 NAFLD 组的骨质疏松症或骨质疏松性骨折风险均高于非 NAFLD 组[OR=1.29，95%CI（1.14，1.47）和 OR=1.36，95%CI（1.25，1.48）]。经过参数调整，男性 NAFLD 组的骨质疏松症或骨质疏松性骨折风险高于非 NAFLD 组[OR=2.10，95%CI（1.36，3.25）]，而女性则无显著差异[OR=1.13，95%CI（0.86，1.48）]。
结论：骨质疏松症或骨质疏松性骨折的患病率和风险与男性和女性的 NAFLD 显著相关。
试验注册：PROSPERO 2022 CRD42022304708。
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