抗癫痫药物对认知功能磁共振成像的影响。
The effects of antiepileptic drugs on cognitive functional magnetic resonance imaging.
作者信息
Beltramini Guilherme Coco, Cendes Fernando, Yasuda Clarissa Lin
机构信息
Laboratory of Neuroimaging, Department of Neurology, University of Campinas, Campinas, SP, Brazil.
出版信息
Quant Imaging Med Surg. 2015 Apr;5(2):238-46. doi: 10.3978/j.issn.2223-4292.2015.01.04.
Abstract
The cognitive dysfunction caused by antiepileptic drugs (AEDs) has been extensively described, although the mechanisms underlying such collateral effects are still poorly understood. The combination of functional magnetic resonance imaging (fMRI) studies with pharmacological intervention (pharmaco-MRI or ph-MRI) offers the opportunity to investigate the effect of drugs such as AEDs on brain activity, including cognitive tasks. Here we review the studies that investigated the effects of AEDs [topiramate (TPM), lamotrigine (LMT), carbamazepine (CBZ), pregabalin (PGB), valproate (VPA) and levetiracetam (LEV)] on cognitive fMRI tasks. Despite the scarcity of fMRI studies focusing on the impact of AEDs on cognitive task, the results of recent work have provided important information about specific drug-related changes of brain function.
摘要
抗癫痫药物（AEDs）引起的认知功能障碍已被广泛描述，尽管这些副作用背后的机制仍知之甚少。功能磁共振成像（fMRI）研究与药物干预（药物MRI或ph-MRI）相结合，为研究诸如AEDs等药物对脑活动（包括认知任务）的影响提供了机会。在此，我们综述了研究AEDs[托吡酯（TPM）、拉莫三嗪（LMT）、卡马西平（CBZ）、普瑞巴林（PGB）、丙戊酸盐（VPA）和左乙拉西坦（LEV）]对认知fMRI任务影响的研究。尽管关注AEDs对认知任务影响的fMRI研究较少，但近期研究结果已提供了有关特定药物相关脑功能变化的重要信息。
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