Tommelein Joke, Verset Laurine, Boterberg Tom, Demetter Pieter, Bracke Marc, De Wever Olivier
Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University , Ghent , Belgium.
Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles , Brussels , Belgium.
Front Oncol. 2015 Mar 23;5:63. doi: 10.3389/fonc.2015.00063. eCollection 2015.
Colorectal cancer (CRC) progression and eventually metastasis is directed in many aspects by a circuitous ecosystem consisting of an extracellular matrix scaffold populated by cancer-associated fibroblasts (CAFs), endothelial cells, and diverse immune cells. CAFs are recruited from local tissue-resident fibroblasts or pericryptal fibroblasts and distant fibroblast precursors. CAFs are highly abundant in CRC. In this review, we apply the metastasis-promoting communication of colorectal CAFs to 10 cancer hallmarks described by Hanahan and Weinberg. CAFs influence innate and adaptive tumor immune responses. Using datasets from previously published work, we re-explore the potential messages implicated in this process. Fibroblasts present in metastasis (metastasis-associated fibroblasts) from CRC may have other characteristics and functional roles than CAFs in the primary tumor. Since CAFs connect metastasis-promoting communication, CAF markers are potential prognostic biomarkers. CAFs and their products are possible targets for novel therapeutic strategies.
结直肠癌（CRC）的进展以及最终的转移在许多方面是由一个复杂的生态系统所引导的，该生态系统由一个细胞外基质支架组成，其中填充着癌症相关成纤维细胞（CAFs）、内皮细胞和多种免疫细胞。CAFs是从局部组织驻留成纤维细胞或隐窝周围成纤维细胞以及远处的成纤维细胞前体招募而来的。CAFs在CRC中高度丰富。在本综述中，我们将结直肠CAFs促进转移的通讯作用应用于Hanahan和Weinberg所描述的10个癌症特征。CAFs影响先天性和适应性肿瘤免疫反应。利用先前发表的工作中的数据集，我们重新探索了这一过程中潜在的信息。CRC转移灶中存在的成纤维细胞（转移相关成纤维细胞）可能具有与原发肿瘤中的CAFs不同的其他特征和功能作用。由于CAFs连接促进转移的通讯，CAF标志物是潜在的预后生物标志物。CAFs及其产物是新型治疗策略的可能靶点。
