Gouge S F, Tietjen D P, Moore J
Department of Medicine, Walter Reed Army Medical Center, Washington, D.C. 20307-5001.
J Reprod Med. 1989 Nov;34(11):931-3.
Intraperitoneal cisplatin has been used for localized tumor control to attain high intraperitoneal concentrations while minimizing systemic toxicity. We report on a woman who developed permanent renal failure following a single intraperitoneal dose of cisplatin. Probable factors contributing to this toxicity were mild renal insufficiency from prior intravenous cisplatin and failure to maintain brisk diuresis in the face of volume depletion due to severe vomiting. Although intraperitoneal cisplatin results in high intraperitoneal drug levels, serum levels similar to those seen with intravenous therapy may contribute to severe nephrotoxicity.
腹腔内注射顺铂已被用于局部肿瘤控制，以达到高腹腔内浓度，同时将全身毒性降至最低。我们报告了一名女性，在单次腹腔注射顺铂后发生了永久性肾衰竭。导致这种毒性的可能因素是既往静脉注射顺铂引起的轻度肾功能不全，以及在严重呕吐导致容量耗竭的情况下未能维持充分的利尿。尽管腹腔内注射顺铂会导致腹腔内药物水平升高，但与静脉治疗相似的血清水平可能会导致严重的肾毒性。
