Misago Noriyuki, Inoue Takuya, Nagase Kotaro, Tsuruta Noriko, Tara-Hashimoto Akiko, Kimura Hiromi, Takahara Kanako, Narita Tomomi, Narisawa Yutaka
Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.
J Dermatol. 2015 Jul;42(7):667-73. doi: 10.1111/1346-8138.12871. Epub 2015 Apr 9.
Follicular squamous cell carcinoma (SCC) with infundibular differentiation includes the common and crater forms of infundibular SCC. We previously considered the crater/ulcerated infundibular SCC to be a progressive condition of the common form and histopathologically studied an additional five cases of the crater/ulcerated infundibular SCC, the results of which suggested the following characteristic histopathological features and possible developmental process in this type of SCC: (i) a considerable number of continuous hyperplastic follicular infundibula, which may develop at the beginning of the disease; (ii) hyperplastic infundibula exhibiting an abrupt or gradual transition to the SCC component, which frequently change relative to the neoplastic infundibular canal; and (iii) the presence of multiple sites of branching of the neoplastic infundibular canals and/or complete involvement of large cysts in the neoplastic process over the center of the lesion, resulting in ulceration. Based on these histopathological findings, we considered that crater/ulcerated infundibular SCC involve a considerable number of continuous follicular infundibula from the start, although some cases may develop from the common form. We also emphasize the possible aggressive biological behavior of the crater/ulcerated form. Keratoacanthoma (KA) is a unique, benign or borderline malignant neoplasm exhibiting follicular (infundibular/isthmic) differentiation characterized by the involvement of continuous follicular infundibula in multiples. From this standpoint, we consider that crater/ulcerated infundibular SCC is possibly related to KA in terms of histogenesis and is a malignant (or high-grade) counterpart of KA.
具有漏斗部分化的滤泡性鳞状细胞癌（SCC）包括常见型和火山口型漏斗部SCC。我们之前认为火山口/溃疡型漏斗部SCC是常见型的进展期病变，并对另外5例火山口/溃疡型漏斗部SCC进行了组织病理学研究，结果显示了这类SCC的以下特征性组织病理学特征和可能的发展过程：（i）相当数量的连续增生性滤泡漏斗部，可能在疾病初期就已形成；（ii）增生性漏斗部突然或逐渐转变为SCC成分，其常相对于肿瘤性漏斗管发生变化；（iii）肿瘤性漏斗管存在多个分支部位和/或病变中心的大囊肿在肿瘤形成过程中完全受累，导致溃疡形成。基于这些组织病理学发现，我们认为火山口/溃疡型漏斗部SCC从一开始就涉及相当数量的连续滤泡漏斗部，尽管有些病例可能由常见型发展而来。我们还强调了火山口/溃疡型的可能侵袭性生物学行为。角化棘皮瘤（KA）是一种独特的、良性或交界性恶性肿瘤，表现出滤泡性（漏斗部/峡部）分化，其特征是多个连续滤泡漏斗部受累。从这个角度来看，我们认为火山口/溃疡型漏斗部SCC在组织发生学上可能与KA相关，是KA的恶性（或高级别）对应物。
