Dellmann H D, Lue L F, Bellin S I, Quassat M
Department of Veterinary Anatomy, College of Veterinary Medicine, Iowa State University, Ames 50011.
J Neurosci Res. 1989 Oct;24(2):163-8. doi: 10.1002/jnr.490240206.
To test the working hypothesis that neurosecretory neuronal regeneration is largely dependent on microenvironmental conditions at the lesion site, intact or predegenerated optic nerves were allografted intrahypothalamically into the hypothalamo-neurohypophysial tract. Neurosecretory axons regenerated consistently into all grafts. Early regeneration proceeded without glial cell association. At later stages of regeneration, however, neurosecretory axons were associated consistently with astrocytes that, within perivascular spaces, were surrounded by a basal lamina. Axons in contact with that basal lamina had the characteristics of terminals, suggesting functional recovery. It is postulated that it is the initial absence of a blood-brain barrier at the graft site that provides a microenvironment similar to that in the neural lobe and that induces neurosecretory axon regeneration.
为了验证神经分泌神经元再生在很大程度上依赖于损伤部位微环境条件这一工作假设，将完整的或预先变性的视神经同种异体移植到下丘脑-神经垂体束的下丘脑内。神经分泌轴突持续再生进入所有移植物。早期再生过程中没有神经胶质细胞的参与。然而，在再生后期，神经分泌轴突始终与星形胶质细胞相关联，这些星形胶质细胞在血管周围间隙中被基膜包围。与该基膜接触的轴突具有终末的特征，提示功能恢复。据推测，移植物部位最初不存在血脑屏障，这提供了一个与神经叶相似的微环境，并诱导神经分泌轴突再生。
