Vildbrad Mads Dam, Andersen Asger, Andersen Thomas Krarup, Axelgaard Sofie, Holmboe Sarah, Andersen Stine, Ringgaard Steffen, Nielsen-Kudsk Jens Erik
Department of Cardiology-Research, Institute of Clinical Medicine, Aarhus University Hospital Skejby, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark.
Physiol Meas. 2015 May;36(5):925-37. doi: 10.1088/0967-3334/36/5/925. Epub 2015 Apr 9.
Right heart failure occurs in various heart and pulmonary vascular diseases and may be fatal. We aimed to identify limitations in non-invasive measurements of right ventricular stroke volume in an animal model of right ventricular failure. Data from previous studies randomising rats to pulmonary trunk banding (PTB, n = 33) causing pressure-overload right ventricular failure or sham operation (n = 16) was evaluated retrospectively. We measured right ventricular stroke volume by high frequency echocardiography and magnetic resonance imaging (MRI). We found correlation between right ventricular stroke volume measured by echocardiography and MRI in the sham animals (r = 0.677, p = 0.004) but not in the PTB group. Echocardiography overestimated the stroke volume compared to MRI in both groups. Intra- and inter-observer variation did not explain the difference. Technical, physiological and anatomical issues in the pulmonary artery might explain why echocardiography over-estimates stroke volume. Flow acceleration close to the pulmonary artery banding can cause uncertainties in the PTB model and might explain the lack of correlation. In conclusion, we found a correlation in right ventricular stroke volume measured by echocardiography versus MRI in the sham group but not the PTB group. Echocardiography overestimated right ventricular stroke volume compared to MRI.
右心衰竭发生于多种心脏和肺血管疾病中，可能会导致死亡。我们旨在确定右心室衰竭动物模型中右心室每搏输出量无创测量的局限性。回顾性评估了先前将大鼠随机分为造成压力超负荷性右心室衰竭的肺动脉束带术（PTB，n = 33）组或假手术组（n = 16）的研究数据。我们通过高频超声心动图和磁共振成像（MRI）测量右心室每搏输出量。我们发现，在假手术动物中，超声心动图测量的右心室每搏输出量与MRI测量结果之间存在相关性（r = 0.677，p = 0.004），但在PTB组中不存在相关性。与MRI相比，两组中超声心动图均高估了每搏输出量。观察者内和观察者间的差异并不能解释这种差异。肺动脉的技术、生理和解剖问题可能解释了为什么超声心动图会高估每搏输出量。靠近肺动脉束带处的血流加速会在PTB模型中导致不确定性，这可能解释了缺乏相关性的原因。总之，我们发现假手术组中超声心动图测量的右心室每搏输出量与MRI测量结果之间存在相关性，但PTB组中不存在。与MRI相比，超声心动图高估了右心室每搏输出量。
