Tomasin Rebeka, de Andrade Rafael Siqueira, Gomes-Marcondes Maria Cristina Cintra
Laboratory of Nutrition and Cancer, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas-UNICAMP , Campinas, São Paulo, Brazil .
J Med Food. 2015 Oct;18(10):1128-35. doi: 10.1089/jmf.2014.0129. Epub 2015 Apr 9.
Oxidative stress has a dual role in cancer; it is linked with tumorigenic events and host wasting, as well as senescence and apoptosis. Researchers have demonstrated the importance of coadjuvant therapies in cancer treatment, and Aloe vera and honey have immunomodulatory, anticancer, and antioxidant properties. The preventive and therapeutic effects of Aloe vera (L.) Burm. f. (Xanthorrhoeaceae) and honey in tumor progression and host wasting were analyzed in Walker 256 carcinoma-bearing rats. The animals were distributed into the following groups: C=control-untreated, W=tumor-untreated, WA=treated after tumor induction, A=control-treated, AW=treated before tumor induction, and AWA=treated before and after tumor induction. Proteolysis and oxidative stress were analyzed in the tumor, liver, muscle, and myocardial tissues. The results suggest that the Aloe vera and honey treatment affect the tumor and host by different mechanisms; the treatment-modulated host wasting and cachexia, whereas it promoted oxidative stress and damage in tumor tissues, particularly in a therapeutic context (WA).
氧化应激在癌症中具有双重作用；它与致瘤事件、宿主消瘦以及衰老和凋亡相关。研究人员已经证明了辅助治疗在癌症治疗中的重要性，而芦荟和蜂蜜具有免疫调节、抗癌和抗氧化特性。在携带Walker 256癌的大鼠中分析了库拉索芦荟（L.）Burm. f.（黄脂木科）和蜂蜜对肿瘤进展和宿主消瘦的预防和治疗作用。将动物分为以下几组：C = 未处理的对照组、W = 未处理的肿瘤组、WA = 肿瘤诱导后处理组、A = 处理的对照组、AW = 肿瘤诱导前处理组、AWA = 肿瘤诱导前后均处理组。分析了肿瘤、肝脏、肌肉和心肌组织中的蛋白水解和氧化应激。结果表明，芦荟和蜂蜜治疗通过不同机制影响肿瘤和宿主；该治疗调节宿主消瘦和恶病质，而它促进肿瘤组织中的氧化应激和损伤，特别是在治疗情况下（WA）。
