[一例IV型埃勒斯-当洛综合征的电子显微镜和免疫组织学研究]
[Electron microscopic and immunohistological studies of a case of Ehlers-Danlos syndrome type IV].
作者信息
Matsuta M, Akasaka T, Kon S, Suzuki Z
出版信息
Nihon Hifuka Gakkai Zasshi. 1989 Apr;99(5):601-7.
PMID:2585774
Abstract
A 5-year-old male considered clinically to have Ehlers-Danlos syndrome (EDS) type IV with main symptoms of fragility and easy bruisability of the skin was presented. Electron microscopic observations of collagen fibers and immunohistological examination of the localization of the type III collagen in the patient revealed dissimilarities in the size and the irregularities in the shape of collagen filaments, as well as a clear difference in localization of type III collagen when compared with normal skin of same age.
摘要
报告了一名5岁男性患者，临床诊断为IV型埃勒斯-当洛综合征（EDS），主要症状为皮肤脆弱和易瘀伤。对该患者的胶原纤维进行电子显微镜观察，并对III型胶原在皮肤中的定位进行免疫组织学检查，结果显示与同年龄正常皮肤相比，胶原纤维丝的大小不同且形状不规则，III型胶原的定位也存在明显差异。
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