非综合征型和综合征型牙源性角化囊性瘤中的金属硫蛋白免疫表达
Metallothionein immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour.
作者信息
Johann Aline-Cristina-Batista-Rodrigues, Caldeira Patrícia-Carlos, Caliari Marcelo-Vidigal, Gomez Ricardo-Santiago, Aguiar Maria-Cássia-Ferreira, Mesquita Ricardo-Alves
机构信息
Universidade Federal de Minas Gerais, Faculdade de Odontologia, Av. Antônio Carlos, 6627 sala 3201, Pampulha, Belo Horizonte, MG, Brasil,
出版信息
Med Oral Patol Oral Cir Bucal. 2015 Jul 1;20(4):e408-12. doi: 10.4317/medoral.20418.
BACKGROUND
To compare the metallothionein (MT) immunoexpression in non-syndromic and syndromic keratocystic odontogenic tumour (KOT), to correlate MT with cellular proliferation, and to evaluate the influence of inflammation in MT.
STUDY DESIGN
Fourteen cases of KOT were submitted to immunohistochemistry for MT and Ki-67 analysis. The lesions were grouped according to their grade of inflammation, and statistical analysis was performed.
RESULTS
MT was higher in non-syndromic KOT than in syndromic KOT (p<0.05). No statistical difference in Ki-67 could be identified; however, an inverse correlation was observed between MT and Ki-67 in both lesions. When analysing inflammation, non-syndromic KOT showed no differences in either MT or Ki-67.
CONCLUSIONS
The MT immunophenotype of syndromic KOT was different from non-syndromic KOT. MT might not be involved in the proliferation control of both KOT. MT and Ki-67 immunoexpressions proved to be unaffected by inflammation in non-syndromic KOT.
背景
比较非综合征性和综合征性牙源性角化囊性瘤（KOT）中金属硫蛋白（MT）的免疫表达，将MT与细胞增殖相关联，并评估炎症对MT的影响。
研究设计
对14例KOT病例进行MT和Ki-67分析的免疫组织化学检测。根据炎症程度对病变进行分组，并进行统计分析。
结果
非综合征性KOT中的MT高于综合征性KOT（p<0.05）。Ki-67未发现统计学差异；然而，在两种病变中MT与Ki-67之间均观察到负相关。分析炎症时，非综合征性KOT在MT或Ki-67方面均无差异。
结论
综合征性KOT的MT免疫表型与非综合征性KOT不同。MT可能不参与两种KOT的增殖控制。在非综合征性KOT中，MT和Ki-67免疫表达被证明不受炎症影响。
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