Yaguchi Y, Tomino Y, Nakamura T, Funabiki K, Shirato I, Ebiiiara I, Nakayama S, Koide H
Nihon Jinzo Gakkai Shi. 1989 Jul;31(7):729-33.
Comparative studies of clinicopathological findings were carried out in 89 patients with adult and juvenile onset of IgA nephropathy. Among 89 patients with IgA nephropathy, there were 42 patients with juvenile onset, i.e less than 19 years old, and 47 patients with adult onset, i.e. more than 35 years old. Clinical activities of both groups were examined as follows; urinary protein, mean blood pressure renal function (PSP 15 min, Ccr) and serum IgA (s-IgA). The histology of renal tissues was also examined by light microscopy and immunofluorescence in both groups. The levels of mean blood pressure or s-IgA in patients with adult onset group were significantly higher than those in patients with juvenile onset group (p less than 0.001). The levels of Ccr in patients with adult onset group were markedly decreased. The patients with more than 1.0g/day of proteinuria and more than 110 mmHg of mean blood pressure showed severe proliferative glomerular injuries by light microscopy. It is suggested that the patients with adult onset of IgA nephropathy show severe progressive and/or exacerbating factors during the clinical course.
对89例成人起病和青少年起病的IgA肾病患者进行了临床病理结果的比较研究。在89例IgA肾病患者中，有42例青少年起病患者，即年龄小于19岁，47例成人起病患者，即年龄大于35岁。对两组的临床活动情况进行了如下检查：尿蛋白、平均血压、肾功能（PSP 15分钟、内生肌酐清除率）和血清IgA（s-IgA）。两组均通过光学显微镜和免疫荧光检查肾组织的组织学情况。成人起病组患者的平均血压或s-IgA水平显著高于青少年起病组患者（p<0.001）。成人起病组患者的内生肌酐清除率水平明显降低。蛋白尿每天超过1.0g且平均血压超过110mmHg的患者通过光学显微镜检查显示有严重的肾小球增殖性损伤。提示成人起病的IgA肾病患者在临床病程中表现出严重的进行性和/或加重因素。
