Li Binghui, Wang Man, Chen Kui, Cheng Zhifeng, Chen Gaojian, Zhang Zexin
Center for Soft Condensed Matter Physics and Interdisciplinary Research & Collaborative Innovation Center of Suzhou Nano Science and Technologyand College of Physics, Optoelectronics and Energy, Soochow University, Suzhou, 215006, China.
Macromol Rapid Commun. 2015 Jun;36(12):1200-4. doi: 10.1002/marc.201500063. Epub 2015 Apr 9.
Janus particles with anisotropic biofunctionalities are perfect models to mimic anisotropic architectures and directional interactions that occur in nature. It is therefore highly desirable to develop reliable and efficient methods to synthesize biofunctional Janus particles. Herein, a facile method combining seeded-emulsion polymerization and thiol-click chemistry has been developed to synthesize Janus particles with glucose moieties on one side. These biofunctional Janus particles show region-selective binding of protein, which represents a big step toward biomimicry, and demonstrates the potential of the bioJanus particles for targeted drug delivery and binding.
具有各向异性生物功能的 Janus 粒子是模拟自然界中出现的各向异性结构和定向相互作用的理想模型。因此，非常需要开发可靠且高效的方法来合成生物功能化的 Janus 粒子。在此，已开发出一种将种子乳液聚合和硫醇点击化学相结合的简便方法，以合成一侧带有葡萄糖部分的 Janus 粒子。这些生物功能化的 Janus 粒子表现出对蛋白质的区域选择性结合，这代表了向生物模拟迈出的一大步，并证明了生物 Janus 粒子在靶向药物递送和结合方面的潜力。
