Sanchez Carole, Le Treut Thérèse, Baier Céline, Sébahoun Gérard, Costello Régis T
APHM, Laboratoire d'Hématologie, Hôpital Nord, Marseille, France; Aix-Marseille Univ, U1090, TAGC, 13008 Marseille, France.
APHM, Laboratoire d'Hématologie, Hôpital Nord, Marseille, France.
Hum Immunol. 2015 Jun;76(6):414-6. doi: 10.1016/j.humimm.2015.03.021. Epub 2015 Apr 6.
Polycythemia vera (PV) is a disease with slow development. Nonetheless, the immune response is unable to eliminate the uncontrolled proliferating hematopoietic cells, leading to treatment of patient by phlebotomy and/or cytotoxic drugs. In addition, a higher incidence of cancers is observed in PV patients, independently of treatment. These observations argue for an impaired immune response in PV. In order to investigate this hypothesis, we studied the distribution of lymphocyte subpopulations in PV, and showed a significant decrease in T, TCR γ/δ and B cells together with an increase in natural killer (NK) cells.
真性红细胞增多症（PV）是一种发展缓慢的疾病。尽管如此，免疫反应无法消除不受控制增殖的造血细胞，导致患者需通过放血和/或细胞毒性药物进行治疗。此外，无论是否接受治疗，PV患者的癌症发病率都较高。这些观察结果表明PV患者的免疫反应受损。为了研究这一假设，我们研究了PV患者淋巴细胞亚群的分布，结果显示T细胞、TCRγ/δ细胞和B细胞显著减少，而自然杀伤（NK）细胞增加。
