Kuwano K, Matsuba K, Ikeda T, Murakami J, Araki A, Nishitani H, Ishida T, Yasumoto K, Kido M, Shigematsu N
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Sep;27(9):1059-65.
To assess the ability of high resolution CT scan and pulmonary function tests in detecting and grading mild emphysema, we correlated the high resolution CT scan and pulmonary function tests with the pathologic grade of emphysema and the destructive index of lung specimens from 42 patients undergoing thoracotomy for solitary pulmonary nodules. Using the high resolution CT scan, we could identify the pathologic grade of mild and moderate emphysema. By measuring diffusing capacity per unit alveolar gas volume (DLco/VA), it seemed to be possible to detect the mildest degree of alveolar destruction assessed by the destructive index, which was not detected by high resolution CT scan. The reason for these results seemed to be that we assessed the severity of emphysema by detecting the air space enlargement on high resolution CT scan images caused by the destruction of alveolar walls, which were detectable by measuring DLco/VA. We conclude that it is possible to detect mild emphysema using the combination of high resolution CT scan and pulmonary function tests.
为评估高分辨率CT扫描和肺功能测试检测轻度肺气肿并对其进行分级的能力，我们将高分辨率CT扫描和肺功能测试与42例因孤立性肺结节接受开胸手术患者的肺气肿病理分级及肺标本破坏指数进行了相关性分析。通过高分辨率CT扫描，我们能够识别轻度和中度肺气肿的病理分级。通过测量单位肺泡气体体积弥散量（DLco/VA），似乎有可能检测到用破坏指数评估的最轻微程度的肺泡破坏，而这是高分辨率CT扫描无法检测到的。出现这些结果的原因似乎是，我们通过检测高分辨率CT扫描图像上由肺泡壁破坏引起的气腔扩大来评估肺气肿的严重程度，而这可以通过测量DLco/VA来检测。我们得出结论，联合使用高分辨率CT扫描和肺功能测试能够检测出轻度肺气肿。
