Kimura I, Tsubta T, Ueda N, Tada S, Yoshimoto S, Sogawa J, Shiraishi T, Tamaki T, Ueno K, Fujita T
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Sep;27(9):1074-81.
A new clinicopathological state related to HTLV-I infection was found in patients with diffuse panbronchiolitis (DPB) and idiopathic interstitial pneumonia (IIP). This specific state with chronic and progressive respiratory symptoms caused by bronchiolar or alveolar disorder was characterized by smoldering adult T-cell leukemia or the HTLV-I carrier state known as HTLV-I associated bronchiolo-alveolar disorder (HABA). The clinical features of 5 cases with the bronchiolar type of HABA and one case with alveolar type of HABA were described and were compatible with the criteria of DPB and IIP, respectively. Long-term subclinical infection of HTLV-I was suspected to play an important role in the pathogenesis of HABA. Furthermore, the investigation of HABA might yield a clue to the unknown etiology of DPB and IIP.
在弥漫性泛细支气管炎（DPB）和特发性间质性肺炎（IIP）患者中发现了一种与人类嗜T淋巴细胞病毒I型（HTLV-I）感染相关的新的临床病理状态。这种由细支气管或肺泡病变引起的具有慢性进行性呼吸道症状的特殊状态，其特征为隐匿性成人T细胞白血病或称为HTLV-I相关细支气管肺泡病变（HABA）的HTLV-I携带者状态。描述了5例细支气管型HABA和1例肺泡型HABA的临床特征，它们分别符合DPB和IIP的标准。HTLV-I的长期亚临床感染被怀疑在HABA的发病机制中起重要作用。此外，对HABA的研究可能会为DPB和IIP的未知病因提供线索。
