Gresser U, Kronawitter U, Adjan O, Zöllner N
Medizinische Poliklinik, Universität München.
Klin Wochenschr. 1989 Oct 17;67(20):1058-60. doi: 10.1007/BF01727008.
A single 50 mg dose of irtemazole was given orally to ten healthy male volunteers. The onset of effects was tested. Plasma uric acid began to decrease 15 to 25 min after irtemazole was administrated. Renal uric acid excretion and uric acid clearance increased 10 to 20 min after drug administration. Maximal renal uric acid excretion (mean 197.4 mg/h) and maximal uric acid clearance (mean 78.4 ml/min) were reached after 15 to 55 min. No side effects were observed. The effects of irtemazole occur earlier than those of benzbromarone. The therapeutic effects of long-term therapy remain to be investigated.
给10名健康男性志愿者口服单次50毫克剂量的irtemazole。测试了其起效情况。irtemazole给药后15至25分钟，血浆尿酸开始下降。给药后10至20分钟，肾脏尿酸排泄和尿酸清除率增加。15至55分钟后达到最大肾脏尿酸排泄量（平均197.4毫克/小时）和最大尿酸清除率（平均78.4毫升/分钟）。未观察到副作用。irtemazole的作用比苯溴马隆出现得更早。长期治疗的疗效仍有待研究。
