Cea Gabriel, Jara Paula, Quevedo Fernando
Rev Med Chil. 2015 Feb;143(2):183-9. doi: 10.4067/S0034-98872015000200005.
Guillain-Barré syndrome (GBS) is the commonest cause of acute flaccid paralysis worldwide, with an incidence of 0.6-4 per 100.000 inhabitants per year. It affects all age groups and carries an incapacity burden of up to 20%.
To describe the features of GBS in adult Chilean patients admitted to a tertiary care hospital.
Review of medical records of 41 patients aged 17 to 81 years (30 males) admitted to a public hospital with the diagnosis of GBS between 2003 and 2009. According to clinical and electrophysiological criteria, the patients were classified into different varieties of GBS.
The incidence of GBS was higher in males (2.7:1) and the demyelinated GBS variety was found in 66% of cases. According to the Hughes disability score, patients treated with plasmapheresis, showed non-statistically significant better outcomes than those treated with intravenous immunoglobulin.
In this group of patients the demyelinated variety of GBS was more common than the axonal type. Although not statistically significant, the better response to plasmapheresis is encouraging and should prompt a controlled study.
吉兰 - 巴雷综合征（GBS）是全球急性弛缓性麻痹最常见的病因，每年每10万居民中的发病率为0.6 - 4例。它影响所有年龄组，造成的失能负担高达20%。
描述在一家三级医院住院的成年智利患者中GBS的特征。
回顾2003年至2009年间在一家公立医院诊断为GBS的41例年龄在17至81岁（30例男性）患者的病历。根据临床和电生理标准，将患者分为不同类型的GBS。
GBS的发病率男性较高（2.7:1），66%的病例为脱髓鞘型GBS。根据休斯残疾评分，接受血浆置换治疗的患者比接受静脉注射免疫球蛋白治疗的患者结局更好，但差异无统计学意义。
在这组患者中，脱髓鞘型GBS比轴索性更常见。虽然差异无统计学意义，但对血浆置换更好的反应令人鼓舞，应促使开展对照研究。
