儿童登革出血热或登革休克综合征
Dengue haemorrhagic fever or dengue shock syndrome in children.
作者信息
Alejandria Marissa M
机构信息
Section of Infectious Diseases, Departments of Medicine and Clinical Epidemiology College of Medicine, University of the Philippines, Manila, The Philippines.
出版信息
BMJ Clin Evid. 2015 Apr 10;2015:0917.
INTRODUCTION
Dengue haemorrhagic fever and dengue shock syndrome are major causes of hospital admission and mortality in children.
METHODS AND OUTCOMES
We conducted a systematic review and aimed to answer the following clinical question: What are the effects of supportive treatments for dengue haemorrhagic fever or dengue shock syndrome in children? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2014 (Clinical Evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
RESULTS
We found nine studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
CONCLUSIONS
In this systematic review we present information relating to the effectiveness and safety of the following interventions: adding blood component transfusion to standard intravenous fluids; adding corticosteroids or intravenous immunoglobulin to standard intravenous fluids; and crystalloids versus colloids.
引言
登革出血热和登革休克综合征是儿童住院和死亡的主要原因。
方法与结果
我们进行了一项系统评价，旨在回答以下临床问题：儿童登革出血热或登革休克综合征支持治疗的效果如何？我们检索了：截至2014年3月的医学期刊数据库（Medline）、荷兰医学文摘数据库（Embase）、考克兰图书馆及其他重要数据库（临床证据综述会定期更新，请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品及医疗保健产品监管局（MHRA）等相关组织的危害警示。
结果
我们发现9项研究符合纳入标准。我们对干预措施的证据质量进行了GRADE评估。
结论
在本系统评价中，我们提供了以下干预措施有效性和安全性的相关信息：在标准静脉输液中添加血液成分输血；在标准静脉输液中添加皮质类固醇或静脉注射免疫球蛋白；晶体液与胶体液的比较。
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