Bachar Sitesh C, Mazumder Kishor, Bachar Ritesh, Aktar Asma, Al Mahtab Mamun
Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Department of Pharmacy, Jashore University of Science and Technology, Jashore, Bangladesh.
Front Pharmacol. 2021 Nov 8;12:732891. doi: 10.3389/fphar.2021.732891. eCollection 2021.
Currently, viral infection is the most serious health issue which causing unexpected higher rate of death globally. Many viruses are not yet curable, such as corona virus-2 (SARS-CoV-2), human immunodeficiency virus (HIV), hepatitis virus, human papilloma virus and so others. Furthermore, the toxicities and ineffective responses to resistant strains of synthetic antiviral drugs have reinforced the search of effective and alternative treatment options, such as plant-derived antiviral drug molecules. Therefore, in the present review, an attempt has been taken to summarize the medicinal plants reported for exhibiting antiviral activities available in Bangladesh along with discussing the mechanistic insights into their bioactive components against three most hazardous viruses, namely SARS-CoV-2, HIV, and HBV. The review covers 46 medicinal plants with antiviral activity from 25 families. Among the reported 79 bioactive compounds having antiviral activities isolated from these plants, about 37 of them have been reported for significant activities against varieties of viruses. Hesperidin, apigenin, luteolin, seselin, 6-gingerol, humulene epoxide, quercetin, kaempferol, curcumin, and epigallocatechin-3-gallate (EGCG) have been reported to inhibit multiple molecular targets of SARS-CoV-2 viral replication in a number of investigations. Besides, numerous , , and bioassays have been demonstrated that EGCG, anolignan-A, and B, ajoene, curcumin, and oleanolic acid exhibit anti-HIV activity while piperine, ursolic acid, oleanolic acid, (+)-cycloolivil-4'-O-β-d-glucopyranoside, quercetin, EGCG, kaempferol, aloin, apigenin, rosmarinic acid, andrographolide, and hesperidin possess anti-HBV activity. Thus, the antiviral medicinal plants and the isolated bioactive compounds may be considered for further advanced investigations with the aim of the development of effective and affordable antiviral drugs.
目前，病毒感染是全球最严重的健康问题，导致意外的高死亡率。许多病毒尚无治愈方法，如新型冠状病毒2（SARS-CoV-2）、人类免疫缺陷病毒（HIV）、肝炎病毒、人乳头瘤病毒等。此外，合成抗病毒药物的毒性以及对耐药菌株的无效反应促使人们寻找有效的替代治疗方案，如植物来源的抗病毒药物分子。因此，在本综述中，我们试图总结孟加拉国报道的具有抗病毒活性的药用植物，并讨论其生物活性成分针对三种最危险病毒（即SARS-CoV-2、HIV和HBV）的作用机制。该综述涵盖了来自25个科的46种具有抗病毒活性的药用植物。在从这些植物中分离出的79种具有抗病毒活性的生物活性化合物中，约37种已被报道对多种病毒具有显著活性。在多项研究中，橙皮苷、芹菜素、木犀草素、蛇床子素、6-姜酚、环氧葎草烯、槲皮素、山奈酚、姜黄素和表没食子儿茶素-3-没食子酸酯（EGCG）已被报道可抑制SARS-CoV-2病毒复制的多个分子靶点。此外，大量的、、和生物测定表明，EGCG、阿诺木脂素-A和B、大蒜素、姜黄素和齐墩果酸具有抗HIV活性，而胡椒碱、熊果酸、齐墩果酸、（+）-环橄榄素-4'-O-β-D-吡喃葡萄糖苷、槲皮素、EGCG、山奈酚、芦荟素、芹菜素、迷迭香酸、穿心莲内酯和橙皮苷具有抗HBV活性。因此，为了开发有效且价格合理的抗病毒药物，可考虑对这些抗病毒药用植物和分离出的生物活性化合物进行进一步深入研究。
