Yamamichi Nobutake, Shimamoto Takeshi, Takahashi Yu, Sakaguchi Yoshiki, Kakimoto Hikaru, Matsuda Rie, Kataoka Yosuke, Saito Itaru, Tsuji Yosuke, Yakabi Seiichi, Takeuchi Chihiro, Minatsuki Chihiro, Niimi Keiko, Asada-Hirayama Itsuko, Nakayama Chiemi, Ono Satoshi, Kodashima Shinya, Yamaguchi Daisuke, Fujishiro Mitsuhiro, Yamaji Yutaka, Wada Ryoichi, Mitsushima Toru, Koike Kazuhiko
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan.
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, Japan; Kameda Medical Center Makuhari, CD-2, 1-3, Nakase, Mihama-ku, Chiba-city, Japan.
PLoS One. 2015 Apr 10;10(4):e0123688. doi: 10.1371/journal.pone.0123688. eCollection 2015.
Despite the marked increase of diverticulosis, its risk factors have not been adequately elucidated. We therefore aim to identify significantly associated factors with diverticulosis. We also aim to investigate the present state of diverticulosis in Japan.
We reviewed the medical records from 1990 to 2010 that included the data of consecutive 62,503 asymptomatic colonoscopy examinees from the general population in Japan. Most recent 3,327 examinees were analyzed with 16 background factors.
Among the 62,503 subjects (47,325 men and 15,178 women; 52.1 ± 9.2 years old), diverticulosis was detected in 11,771 subjects (18.8%; 10,023 men and 1,748 women). The incidences of diverticulosis in 1990-2000 and 2001-2010 were respectively 13.0% (3,771 of 29,071) and 23.9% (8,000 of 33,432): the latter was much higher than the former in all age groups and for both genders. Considering the anatomical locations of colorectal diverticula, left-sided ones have markedly increased with age but not significantly changed with times. Univariate analyses of the 3,327 subjects showed significant association of diverticulosis with four basic factors (age, sex, body mass index, blood pressure), three life style-related factor (smoking, drinking, severe weight increase in adulthood), and two blood test values (triglyceride, HbA1c). The multiple logistic analysis calculating standardized coefficients (β) and odds ratio (OR) demonstrated that age (β = 0.217-0.674, OR = 1.24-1.96), male gender (β = 0.185, OR = 1.20), smoking (β = 0.142-0.200, OR = 1.15-1.22), severe weight increase in adulthood (β = 0.153, OR = 1.17), HbA1c (β = 0.136, OR = 1.15), drinking (β = 0.109, OR = 1.11), and serum triglyceride (β = 0.098, OR = 1.10) showed significantly positive association with diverticulosis whereas body mass index and blood pressure did not.
The large-scale data of asymptomatic colonoscopy examinees from the general population from 1990 to 2010 indicated that the prevalence of diverticulosis is still increasing in Japan. Age, male gender, smoking, severe weight increase in adulthood, serum HbA1c, drinking, and serum triglyceride showed significant positive association with diverticulosis.
尽管憩室病的发病率显著上升，但其危险因素尚未得到充分阐明。因此，我们旨在确定与憩室病显著相关的因素。我们还旨在调查日本憩室病的现状。
我们回顾了1990年至2010年的医疗记录，这些记录包含了来自日本普通人群的连续62503例无症状结肠镜检查受检者的数据。对最近的3327例受检者的16项背景因素进行了分析。
在62503名受试者（47325名男性和15178名女性；平均年龄52.1±9.2岁）中，11771名受试者（18.8%；10023名男性和1748名女性）被检测出患有憩室病。1990 - 2000年和2001 - 2010年憩室病的发病率分别为13.0%（29071例中的3771例）和23.9%（33432例中的8000例）：在所有年龄组和两性中，后者均远高于前者。考虑到结直肠憩室的解剖位置，左侧憩室随年龄显著增加，但随时间无显著变化。对3327名受试者的单因素分析显示，憩室病与四个基本因素（年龄、性别、体重指数、血压）、三个生活方式相关因素（吸烟、饮酒、成年期体重严重增加）以及两个血液检测值（甘油三酯、糖化血红蛋白）显著相关。多元逻辑分析计算标准化系数（β）和比值比（OR）表明，年龄（β = 0.217 - 0.674，OR = 1.24 - 1.96）、男性（β = 0.185，OR = 1.20）、吸烟（β = 0.142 - 0.200，OR = 1.15 - 1.22）、成年期体重严重增加（β = 0.153，OR = 1.17）、糖化血红蛋白（β = 0.136，OR = 1.15）、饮酒（β = 0.109，OR = 1.11）和血清甘油三酯（β = 0.098，OR = 1.10）与憩室病呈显著正相关，而体重指数和血压则不然。
1990年至2010年来自普通人群的无症状结肠镜检查受检者的大规模数据表明，日本憩室病的患病率仍在上升。年龄、男性、吸烟、成年期体重严重增加、血清糖化血红蛋白、饮酒和血清甘油三酯与憩室病呈显著正相关。
