Van de Water A, Verheyen J, Xhonneux R, Reneman R S
Department of Cardiovascular Pharmacology, Janssen Research Foundation,Beerse, Belgium.
J Pharmacol Methods. 1989 Nov;22(3):207-17. doi: 10.1016/0160-5402(89)90015-6.
The adequacy of the Bazett formula to correct for heart rate-induced changes in the QT interval of the electrocardiogram has been frequently questioned. In the present study, a simple linear equation was derived, which in anesthetized dogs corrects more adequately for changes in heart rate than the Bazett formula. Regression analysis of experimental data yielded the following equation: QTc = QT - 0.087 (RR - 1000) = QT - 87 (60/HR - 1). The reliability of this equation was investigated in experiments on anesthetized dogs with different cardioactive drugs with a known mechanism of action.
