Lo Tsia-Shu, Bt Karim Nazura, Nawawi Enie Akhtar, Wu Pei-Ying, Nusee Zalina
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Keelung, Keelung Medical Centre, 222, Maijin Road, Keelung, Taiwan, 204, Republic of China,
Int Urogynecol J. 2015 Sep;26(9):1313-9. doi: 10.1007/s00192-015-2685-x. Epub 2015 Apr 11.
The aim of this study was to look for possible predictors preoperatively for the development of de novo stress urinary incontinence (SUI) in urodynamically continent women who underwent pelvic reconstructive surgery (PRS).
Medical records of 637 continent women who underwent PRS for severe prolapse from January 2005 to December 2013 in our institutions were included in this study. We excluded women who had urodynamic stress incontinence (UDI) either occult or overt, detrusor overactivity, neurogenic bladder-voiding dysfunction, and previous anti-incontinent surgery. Primary outcome measure was the development of de novo SUI at 6 months to 1 year post operation.
Of women in this study, 11 % developed postoperative de novo SUI at 6 months to 1 year of follow-up. Women older than 66 years were 2.86 times [95 % confidence interval (CI) 1.01-2.53, p = 0.14], diabetes mellitus (DM) 2.18 times (95 % CI 1.63-4.21, p = 0.002), certain type of transvaginal mesh procedure 3.5 times (95 % CI, p < 0.001), maximum urethral closure pressure (MUCP) < 60 mmH20 4.65 times (95 % CI, 2.87-8.64, p < 0.001), and functional urethral length (FUL) < 2 cm 3.48 times (95 % CI, 2.13-5.83, p < 0.001) at greater risk of developing de novo SUI.
Continent women with advanced pelvic organ prolapse (POP) > 66 years, with DM or low MUCP and FUL values during preoperative urodynamic evaluation have higher risk of developing de novo SUI; therefore, we suggest counselling such women for concomitant PRS and anti-incontinent surgery.
本研究旨在寻找在接受盆腔重建手术(PRS)的尿动力学检查显示控尿功能正常的女性中,术前可能预测新发压力性尿失禁(SUI)发生的因素。
本研究纳入了2005年1月至2013年12月期间在我们机构因严重盆腔器官脱垂接受PRS的637名控尿功能正常女性的病历。我们排除了隐匿性或显性尿动力学压力性尿失禁(UDI)、逼尿肌过度活动、神经源性膀胱排尿功能障碍以及既往接受过抗尿失禁手术的女性。主要观察指标是术后6个月至1年新发SUI的发生情况。
在本研究的女性中,11%在随访6个月至1年时出现术后新发SUI。年龄大于66岁的女性发生新发SUI的风险是2.86倍[95%置信区间(CI)1.01 - 2.53,p = 0.14],患有糖尿病(DM)的女性是2.18倍(95% CI 1.63 - 4.21,p = 0.002),接受某种经阴道网片手术的女性是3.5倍(95% CI,p < 0.001),最大尿道闭合压(MUCP)< 60 mmHg₂O的女性是4.65倍(95% CI,2.87 - 8.64,p < 0.001),功能性尿道长度(FUL)< 2 cm的女性是3.48倍(95% CI,2.13 - 5.83,p < 0.001)。
年龄大于66岁、患有DM或术前尿动力学评估时MUCP和FUL值较低的盆腔器官脱垂(POP)严重的控尿功能正常女性发生新发SUI的风险较高;因此,我们建议向这些女性提供关于同时进行PRS和抗尿失禁手术的咨询。