Kanitakis Jean, Karayannopoulou Georgia, Roux Adeline, Euvrard Sylvie
Department of Dermatology, Ed. Herriot Hospital Group, Lyon, France Department of Pathology, Ed. Herriot Hospital Group, Lyon, France
Department of Pathology, Ed. Herriot Hospital Group, Lyon, France Department of Pathology, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
Anticancer Res. 2015 Apr;35(4):2305-8.
Squamous cell carcinomas (SCC), the commonest malignancies developing in organ-transplant recipients (OTR), may behave aggressively. We searched for pathological features of post-transplant SCC that could predict an aggressive outcome early.
We pathologically examined 34 SCC developed in OTR that developed later recurrences/metastases, and compared them with 25 non-aggressive SCC excised from the same OTRs over the same period of time for features believed to predict an aggressive outcome (tumour size and thickness, ulceration, deep tissue invasion, mitotic rate, differentiation, peritumoural infiltrate density, acantholysis, perineural and lymphovascular invasion).
A statistically significant difference was found for the level of tumour invasion (Clark), as 58% (18/34) of aggressive SCCs (vs 24% (6/25) of non-aggressive SCCs) were of levels IV or V.
Post-transplant SCCs with a Clark level of IV or V are associated with a higher risk for recurrence and metastasis and call for a close patient follow-up.
鳞状细胞癌（SCC）是器官移植受者（OTR）中最常见的恶性肿瘤，其行为可能具有侵袭性。我们寻找移植后SCC的病理特征，以便早期预测侵袭性结局。
我们对34例OTR中发生的SCC进行了病理检查，这些SCC后来出现复发/转移，并将它们与同期从相同OTR中切除的25例非侵袭性SCC进行比较，以寻找被认为可预测侵袭性结局的特征（肿瘤大小和厚度、溃疡、深部组织浸润、有丝分裂率、分化程度、肿瘤周围浸润密度、棘层松解、神经周和淋巴管浸润）。
发现肿瘤浸润水平（克拉克分级）存在统计学显著差异，侵袭性SCC中有58%（18/34）为IV级或V级（而非侵袭性SCC中为24%（6/25））。
克拉克分级为IV级或V级的移植后SCC与更高的复发和转移风险相关，需要对患者进行密切随访。
