Dermatology and Skin Cancer Center, Leawood, Kansas, USA.
Dermatol Surg. 2010 Feb;36(2):185-93. doi: 10.1111/j.1524-4725.2009.01422.x. Epub 2009 Dec 21.
The scalp is a target for squamous cell carcinoma (SCC) in male organ transplant recipients (OTRs) with alopecia. These tumors can behave aggressively and are associated with high recurrence, morbidity, and mortality. Treatment guidelines are needed for SCC in the scalp of OTRs.
To explore the clinical and histologic features associated with SCC recurrence and aggressiveness in the scalp of OTRs. We review the mechanisms involved as they relate to a case. An algorithm for evaluation and treatment is introduced.
An OTR presented with poorly differentiated SCC of the scalp that recurred on three occasions after Mohs micrographic surgery (MMS). The final recurrence invaded the bone and cranial cavity. We discuss the difficulties encountered in evaluating and treating these patients.
This patient had multiple factors associated with high tumor recurrence and aggressiveness. These were explored, and an algorithm was created.
SCC in the scalp of OTRs presents challenges for evaluation and management. We must be vigilant to monitor for recurrence, perineural invasion, bone invasion, multiple-field tumors, and metastasis. An understanding of the mechanisms of tumor recurrence will assist us in preventing morbidity and mortality in this subset of patients.
脱发男性器官移植受者（OTR）的头皮是鳞状细胞癌（SCC）的靶标。这些肿瘤可能具有侵袭性，与高复发率、发病率和死亡率相关。OTR 头皮 SCC 需要治疗指南。
探讨与 OTR 头皮 SCC 复发和侵袭性相关的临床和组织学特征。我们研究了与病例相关的涉及机制，并引入了一种评估和治疗的算法。
一名 OTR 出现头皮低分化 SCC，经 Mohs 显微外科手术（MMS）三次复发。最终的复发侵犯了骨骼和颅腔。我们讨论了评估和治疗这些患者所遇到的困难。
该患者有多种与高肿瘤复发和侵袭性相关的因素。这些因素得到了探讨，并创建了一个算法。
OTR 头皮 SCC 的评估和管理具有挑战性。我们必须保持警惕，监测复发、神经周围浸润、骨浸润、多灶性肿瘤和转移。对肿瘤复发机制的理解将有助于我们预防这部分患者的发病率和死亡率。
