Aoyama Toru, Murakawa Masaaki, Katayama Yusuke, Yamaoku Koichiro, Kanazawa Amane, Higuchi Akio, Shiozawa Manabu, Morimoto Manabu, Yoshikawa Takaki, Yamamoto Naoto, Rino Yasushi, Masuda Munetaka, Morinaga Soichiro
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Anticancer Res. 2015 Apr;35(4):2401-9.
We investigated the impact of postoperative complications on survival and recurrence after curative surgery for pancreatic cancer.
This study included 164 patients who underwent curative surgery for pancreatic cancer between 2005 and 2014. The patients were classified into those with postoperative complications (C group) and those without postoperative complications (NC group). The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.
Postoperative complications were found in 61 out of the 164 patients (37.2%). The RFS rate at five years after surgery was 10.6% in the C group and 21.0% in the NC group. The RFS tended to be worse in the C group than in the NC group (p=0.1756). The OS rate at five years after surgery was 7.4% in the C group and 22.8% in the NC group, which was significantly different (p=0.0189). The multivariate analysis demonstrated that the occurrence of postoperative complications was a significant independent risk factor for OS and a marginally significant risk factor for RFS.
The development of postoperative complications was a risk factor for a decreased overall survival in the patients who underwent curative surgery for pancreatic cancer. The surgical procedure, perioperative care and the surgical strategy should be carefully planned to avoid complications.
我们研究了胰腺癌根治性手术后术后并发症对生存和复发的影响。
本研究纳入了2005年至2014年间接受胰腺癌根治性手术的164例患者。将患者分为有术后并发症的患者（C组）和无术后并发症的患者（NC组）。确定总生存（OS）和无复发生存（RFS）的危险因素。
164例患者中有61例（37.2%）出现术后并发症。C组术后五年的RFS率为10.6%，NC组为21.0%。C组的RFS往往比NC组更差（p = 0.1756）。C组术后五年的OS率为7.4%，NC组为22.8%，差异有统计学意义（p = 0.0189）。多因素分析表明，术后并发症的发生是OS的显著独立危险因素，也是RFS的边缘显著危险因素。
术后并发症的发生是接受胰腺癌根治性手术患者总生存降低的危险因素。应仔细规划手术程序、围手术期护理和手术策略以避免并发症。
