[过去20年诊断的155例嗜铬细胞瘤-副神经节瘤综合征患者的实验室数据分析]

[Analysis of laboratory data of 155 patients with pheochromocytoma-paraganglioma syndrome diagnosed during the past 20 years].

作者信息

Balog Beatrice, Tőke Judit, Róna Kálmán, Szücs Nikolette, Igaz Péter, Pusztai Péter, Sármán Beatrix, Gláz Edit, Kiss Róbert, Patócs Attila, Rácz Károly, Tóth Miklós

机构信息

Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088.

Semmelweis Egyetem, Általános Orvostudományi Kar Igazságügyi és Biztosítás-orvostani Intézet Budapest.

出版信息

Orv Hetil. 2015 Apr 19;156(16):626-35. doi: 10.1556/OH.2015.30127.

DOI:10.1556/OH.2015.30127

PMID:25864138

Abstract

INTRODUCTION

Laboratory diagnosis of pheochromocytoma-paraganglioma syndrome has been markedly improved during the past two decades.

AIM

Retrospective assessment of diagnostic utility of urinary catecholamines and their metabolites as well as serum chromogranin A in 155 patients diagnosed at the 2nd Department of Medicine, Semmelweis University.

METHOD

Urinary catecholamines and metabolites were measured using high-performance liquid chromatography with electrochemical detection in 155 patients with pheochromocytoma-paraganglioma (of whom 28.4% had hereditary background) and in 170 non-pheochromocytoma patients used as controls. Serum chromogranin A was measured by immunoradiometry.

RESULTS

Sensitivity (93.2%) and specificity (87.0%) of urinary fractionated metanephrines were higher than those of urinary catecholamines (90.9% vs. 85.7%, respectively) and serum chromogranin A (88.7% and 77.5%, respectively). Urinary normetanephrine and serum chromogranin A correlated positively with tumor size (r = 0.552, p<0.0001 and r = 0.618, p<0.0001, respectively).

CONCLUSIONS

These data confirm the diagnostic utility of urinary catecholamines and their metabolites. Urinary normetanephrine and serum chromogranin A may help to estimate tumour mass and probably tumour progression.

摘要