Khodzhibekova M M, Tiutin L A, Kostenikov N A, Il'in N V, Vinogradova Iu N
Vestn Rentgenol Radiol. 2015 Jan-Feb(1):16-21.
To investigate the diagnostic value of 18F-FDG positron emission tomography (PET) in the diagnosis and staging of marginal zone non-Hodgkin lymphomas (NHLs).
Twenty-four patients with new-onset NHLs were examined. Extranodal MALT lymphoma, splenic marginal zone lymphoma (MZL), and nodal MZL lymphoma were diagnosed in 18, 3, and 3 patients, respectively. 18F-FDG PET was carried out by the standard protocol via whole-body examination, by estimating the standardized tracer uptake value (SUV(max)) in the abnormal foci.
Most (83.3%) of the examinees were found to have abnormal tracer hyperfixation foci. The mean SUV(max) was 5.05 ± 0.9. There was no correlation between SUV(max) in the tumor foci and their metabolic sizes (r = 0.1; p = 0.7). No significant differences between the mean SUV(max) were found in patients with different histological types of MZL (p > 0.05). Disease staging by PET and other diagnostic methods yielded contradictory results in three patients. The final analysis suggested that the stage had been correctly determined in all the 3 patients from PET findings.
The results of 18F-FDG PET suggest that it is of high iagnostic value in imag-ng marginal zone NHLs. The major advantage of PET is that it can accu-ately stage the disease, which can provide a ra-ionale for optimal treat-ent policy.
探讨18F-FDG正电子发射断层扫描(PET)在边缘区非霍奇金淋巴瘤(NHL)诊断及分期中的价值。
对24例新发NHL患者进行检查。分别在18例、3例和3例患者中诊断出结外黏膜相关淋巴组织淋巴瘤、脾边缘区淋巴瘤(MZL)和结内MZL淋巴瘤。18F-FDG PET通过标准方案进行全身检查，通过估计异常病灶中的标准化示踪剂摄取值(SUV(max))来进行。
大多数(83.3%)受检者发现有异常示踪剂高摄取灶。平均SUV(max)为5.05±0.9。肿瘤灶中的SUV(max)与其代谢大小之间无相关性(r = 0.1；p = 0.7)。不同组织学类型的MZL患者的平均SUV(max)之间未发现显著差异(p>0.05)。PET与其他诊断方法进行疾病分期时，3例患者结果相互矛盾。最终分析表明，根据PET结果，所有3例患者的分期均正确确定。
18F-FDG PET结果表明，其在边缘区NHL成像中具有较高的诊断价值。PET的主要优势在于它可以准确地对疾病进行分期，这可为优化治疗策略提供依据。
