Pang Q M, Li K, Ma L J, Sun R P
Pediatric Department, Qilu Hospital of Shandong University, Jinan, China.
Department of Gynaecology and Obstetrics, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, China.
J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1):131-4.
In recent years, more and more scholars tend to study neuroblastoma (NB) since it possesses increasing morbidity, but lack of effective treatment. This paper aims to investigate variation and clinical significance of the neuron-specific enolase (NSE) and lactic dehydrogenase (LDH) level in serum of children with NB before and after Auto Peripheral Blood Stem Cell Transplantation (APBSCT). A total of 90 children with NB from various hospitals were included in this research, and we analyzed the relationship between levels of NSE and LDH and the change of disease by comparing the two levels before and after APBSCT treatment. The results indicated that the positive rate of NSE in serum was high before treatment, and the levels of NSE and LDH were remarkably higher than those when the treatment was valid; after comprehensive treatment of chemotherapy, excision and radiotherapy, there was a significant difference of NSE and LDH levels in serum between children with complete remission (CR) and those with partial remission (PR); however, no significant differences of NSE and LDH levels were found among children in progressive stage compared to before treatment. It is believed that NSE and LDH levels are associated to the recurrence and treatment effect of NB, proving that both can reflect tumor load, therefore they can be taken as the auxiliary indicators for monitoring curative effects of NB treatment.
近年来，由于神经母细胞瘤（NB）发病率不断上升但缺乏有效治疗方法，越来越多的学者倾向于对其进行研究。本文旨在探讨自体外周血干细胞移植（APBSCT）前后NB患儿血清中神经元特异性烯醇化酶（NSE）和乳酸脱氢酶（LDH）水平的变化及其临床意义。本研究共纳入了来自不同医院的90例NB患儿，通过比较APBSCT治疗前后这两种酶的水平，分析NSE和LDH水平与疾病变化之间的关系。结果表明，治疗前血清NSE阳性率较高，且NSE和LDH水平显著高于治疗有效的时候；在化疗、手术切除及放疗综合治疗后，完全缓解（CR）患儿与部分缓解（PR）患儿血清中NSE和LDH水平存在显著差异；然而，进展期患儿与治疗前相比，NSE和LDH水平无显著差异。认为NSE和LDH水平与NB的复发及治疗效果相关，证明二者均可反映肿瘤负荷，因此可作为监测NB治疗疗效的辅助指标。
