İnci Mehmet, Baydilli Numan, Akçay Adnan Burak, Demirtaş Abdullah, Rifaioğlu Mehmet Murat, Gözükara Kerem Han, Kaya Mehmet Güngör
Department of Urology, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey.
Department of Urology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Urology. 2015 Jun;85(6):1436-40. doi: 10.1016/j.urology.2015.02.031. Epub 2015 Apr 9.
To investigate benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) in patients with coronary artery ectasia (CAE). The relation between CAE, BPE, and LUTS has not been studied so far.
We investigated BPE and LUTS symptoms in 47 men with CAE, 45 men with coronary artery disease (CAD), and 47 male controls with normal coronary arteries. LUTS was evaluated by the International Prostate Symptom Score (IPSS). BPE was evaluated with transabdominal ultrasonography. CAD was defined as myocardial infarction and angiographically diagnosed coronary disease. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation ≥1.5 fold of the adjacent normal coronary segments.
Prostate volume was higher in CAE and CAD patients compared with that of the control subjects, respectively (41.0 ± 10.4 vs 33.5 ± 9.4 cm(3); 39.1 ± 10.3 vs 33.5 ± 9.4 cm(3); P = .0001); total IPSS was higher in CAD and CAE patients compared with that of the control subjects (P = .0001). Postmictional residual urine volume was higher in CAE and CAD patients compared with that of the control subjects (P = .002).
We showed that patients with CAE have higher prostate volume, IPSS, and postmictional residual urine volume compared with those of controls with normal coronary angiograms. This study proposes that BPE, LUTS, and CAE maybe different disorders to a common vascular pathology and endothelial dysfunction. This study showed that BPE and LUTS were frequently seen in CAE at least as much as in CAD. Therefore, LUTS and BPE should be kept in mind for CAE patients in follow-ups.
研究冠状动脉扩张（CAE）患者的良性前列腺增生（BPE）及下尿路症状（LUTS）。目前尚未对CAE、BPE和LUTS之间的关系进行研究。
我们调查了47例CAE男性患者、45例冠状动脉疾病（CAD）男性患者以及47例冠状动脉正常的男性对照者的BPE和LUTS症状。采用国际前列腺症状评分（IPSS）评估LUTS。通过经腹超声检查评估BPE。CAD定义为心肌梗死和经血管造影诊断的冠状动脉疾病。CAE定义为冠状动脉无任何狭窄病变，通过冠状动脉的视觉评估显示管腔扩张≥相邻正常冠状动脉节段的1.5倍。
与对照组相比，CAE和CAD患者的前列腺体积分别更高（41.0±10.4 vs 33.5±9.4 cm³；39.1±10.3 vs 33.5±9.4 cm³；P = 0.0001）；与对照组相比，CAD和CAE患者的IPSS总分更高（P = 0.0001）。与对照组相比，CAE和CAD患者的排尿后残余尿量更高（P = 0.002）。
我们发现，与冠状动脉造影正常的对照组相比，CAE患者的前列腺体积、IPSS和排尿后残余尿量更高。本研究提出，BPE、LUTS和CAE可能是同一血管病理和内皮功能障碍的不同表现。本研究表明，CAE中BPE和LUTS的常见程度至少与CAD相同。因此，在对CAE患者进行随访时应考虑LUTS和BPE。
