Highly chemoselective and versatile method for direct conversion of carboxylic acids to ketones utilizing zinc ate complexes.
作者信息
Murata Ryo, Hirano Keiichi, Uchiyama Masanobu
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Advanced Elements Chemistry Research Team, RIKEN Center for Sustainable Resource Science, and Elements Chemistry Laboratory, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
出版信息
Chem Asian J. 2015 Jun;10(6):1286-90. doi: 10.1002/asia.201500308. Epub 2015 May 5.
Various carboxylic acids were directly transformed into the corresponding ketones by utilizing organozinc ate complexes, which provide high chemoselectivity without any overreaction to the undesired tertiary carbinol, owing to formation of a stable tetrahedral zincioketal intermediate. This method offers good overall atom/step/pot economy and operational simplicity.
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