Paszynska Elzbieta, Dmitrzak-Weglarz Monika, Slopien Agnieszka, Tyszkiewicz-Nwafor Marta, Rajewski Andrzej
a Department of Biomaterials and Experimental Dentistry , Poznan University of Medical Sciences , Poznan , Poland.
b Psychiatric Genetics Unit, Department of Psychiatry , Poznan University of Medical Sciences , Poznan , Poland.
World J Biol Psychiatry. 2016 Dec;17(8):615-621. doi: 10.3109/15622975.2015.1023356. Epub 2015 Apr 13.
The purpose of this study was to measure the salivary and serum free IGF-1 concentration of patients with anorexia nervosa (AN) in comparison to an average population.
A controlled clinical trial was designed for an age- and gender-matched group of 121 AN patients and 77 healthy individuals. A clinical examination was made and blood and salivary samples were taken during the acute stage of AN (BMI < 15 kg/m) in the first week of hospitalization. An enzyme immunoassay (ELISA) suitable for measuring free IGF-1 was used.
Anorexic patients had significant reductions in salivary unstimulated flow rate (UFR), pH and free IGF-1 levels in their saliva and serum. Significant correlations between serum IGF-1 and BMI; salivary IGF-1 and UFR and pH were detected.
Salivary and serum IGF-1 analyses appear to be a reliable biochemical indicator of malnutrition in AN patients. Measurement of salivary IGF-1 levels would allow new perspectives in monitoring AN in its early stages.
本研究旨在测量神经性厌食症（AN）患者唾液和血清中游离胰岛素样生长因子-1（IGF-1）的浓度，并与普通人群进行比较。
针对121名AN患者和77名健康个体设计了一项年龄和性别匹配的对照临床试验。在住院第一周AN急性期（BMI < 15 kg/m）进行临床检查并采集血液和唾液样本。使用适合测量游离IGF-1的酶免疫测定法（ELISA）。
厌食症患者唾液的非刺激性流速（UFR）、pH值以及唾液和血清中的游离IGF-1水平均显著降低。检测到血清IGF-1与BMI、唾液IGF-1与UFR及pH之间存在显著相关性。
唾液和血清IGF-1分析似乎是AN患者营养不良的可靠生化指标。测量唾液IGF-1水平将为早期监测AN提供新的视角。
