表达多谱系集落刺激因子基因的造血干细胞和祖细胞向生长因子自主性和致瘤性的突变率有所不同。
Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.
作者信息
Laker C, Kluge N, Stocking C, Just U, Franz M J, Ostertag W, DeLamarter J F, Dexter M, Spooncer E
机构信息
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Federal Republic of Germany.
出版信息
Mol Cell Biol. 1989 Dec;9(12):5746-9. doi: 10.1128/mcb.9.12.5746-5749.1989.
Abstract
At least two separate but interdependent events are required to attain autonomous growth as a consequence of ectopic expression of the multilineage colony-stimulating factor gene in hematopoietic progenitor cells. The rate at which the second event occurs is more than 3 orders of magnitude higher in precursor cell lines (FDC-P1 or FDC-P2) than in stem cell lines (FDC-Pmix). Autonomous, but not density-dependent, growth is tightly coupled to tumorigenicity in precursor cells; however, neither growth-factor-independent nor autonomously growing stem cell lines are tumorigenic.
摘要
造血祖细胞中多谱系集落刺激因子基因的异位表达导致自主生长，这至少需要两个独立但相互依赖的事件。第二个事件发生的速率在前体细胞系（FDC-P1或FDC-P2）中比在干细胞系（FDC-Pmix）中高3个数量级以上。前体细胞中自主生长而非密度依赖性生长与致瘤性紧密相关；然而，既不依赖生长因子也不自主生长的干细胞系都不具有致瘤性。
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