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静脉输液和冲洗液加温以预防围手术期意外体温过低。

Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia.

作者信息

Campbell Gillian, Alderson Phil, Smith Andrew F, Warttig Sheryl

机构信息

Department of Anaesthesia, Ninewells Hospital, Dundee, UK, DD1 9SY.

出版信息

Cochrane Database Syst Rev. 2015 Apr 13;2015(4):CD009891. doi: 10.1002/14651858.CD009891.pub2.


DOI:10.1002/14651858.CD009891.pub2
PMID:25866139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6769178/
Abstract

BACKGROUND: Inadvertent perioperative hypothermia (a drop in core temperature to below 36°C) occurs because of interference with normal temperature regulation by anaesthetic drugs, exposure of skin for prolonged periods and receipt of large volumes of intravenous and irrigation fluids. If the temperature of these fluids is below core body temperature, they can cause significant heat loss. Warming intravenous and irrigation fluids to core body temperature or above might prevent some of this heat loss and subsequent hypothermia. OBJECTIVES: To estimate the effectiveness of preoperative or intraoperative warming, or both, of intravenous and irrigation fluids in preventing perioperative hypothermia and its complications during surgery in adults. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (2014, Issue 2), MEDLINE Ovid SP (1956 to 4 February 2014), EMBASE Ovid SP (1982 to 4 February 2014), the Institute for Scientific Information (ISI) Web of Science (1950 to 4 February 2014), Cumulative Index to Nursing and Allied Health Literature (CINAHL) EBSCOhost (1980 to 4 February 2014) and reference lists of identified articles. We also searched the Current Controlled Trials website and ClinicalTrials.gov. SELECTION CRITERIA: We included randomized controlled trials or quasi-randomized controlled trials comparing fluid warming methods versus standard care or versus other warming methods used to maintain normothermia. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data from eligible trials and settled disputes with a third review author. We contacted study authors to ask for additional details when needed. We collected data on adverse events only if they were reported in the trials. MAIN RESULTS: We included in this review 24 studies with a total of 1250 participants. The trials included various numbers and types of participants. Investigators used a range of methods to warm fluids to temperatures between 37°C and 41°C. We found that evidence was of moderate quality because descriptions of trial design were often unclear, resulting in high or unclear risk of bias due to inappropriate or unclear randomization and blinding procedures. These factors may have influenced results in some way. Our protocol specified the risk of hypothermia as the primary outcome; as no trials reported this, we decided to include data related to mean core temperature. The only secondary outcome reported in the trials that provided useable data was shivering. Evidence was unclear regarding the effects of fluid warming on bleeding. No data were reported on our other specified outcomes of cardiovascular complications, infection, pressure ulcers, bleeding, mortality, length of stay, unplanned intensive care admission and adverse events.Researchers found that warmed intravenous fluids kept the core temperature of study participants about half a degree warmer than that of participants given room temperature intravenous fluids at 30, 60, 90 and 120 minutes, and at the end of surgery. Warmed intravenous fluids also further reduced the risk of shivering compared with room temperature intravenous fluidsInvestigators reported no statistically significant differences in core body temperature or shivering between individuals given warmed and room temperature irrigation fluids. AUTHORS' CONCLUSIONS: Warm intravenous fluids appear to keep patients warmer during surgery than room temperature fluids. It is unclear whether the actual differences in temperature are clinically meaningful, or if other benefits or harms are associated with the use of warmed fluids. It is also unclear if using fluid warming in addition to other warming methods confers any benefit, as a ceiling effect is likely when multiple methods of warming are used.

摘要

背景:围手术期意外低温(核心体温降至36°C以下)是由于麻醉药物干扰正常体温调节、长时间皮肤暴露以及大量静脉输液和冲洗液的输入所致。如果这些液体的温度低于核心体温,它们会导致显著的热量散失。将静脉输液和冲洗液加热至核心体温或以上可能会预防部分此类热量散失及随后的低温。 目的:评估术前或术中对静脉输液和冲洗液进行加热,或两者同时加热,在预防成人手术期间围手术期低温及其并发症方面的有效性。 检索方法:我们检索了Cochrane对照试验中心注册库(CENTRAL)(2014年第2期)、MEDLINE Ovid SP(1956年至2014年2月4日)、EMBASE Ovid SP(1982年至2014年2月4日)、科学信息研究所(ISI)科学引文索引(1950年至2014年2月4日)、护理及相关健康文献累积索引(CINAHL)EBSCOhost(1980年至2014年2月4日)以及已识别文章的参考文献列表。我们还检索了当前对照试验网站和ClinicalTrials.gov。 选择标准:我们纳入了比较液体加热方法与标准护理或与用于维持正常体温的其他加热方法的随机对照试验或半随机对照试验。 数据收集与分析:两位综述作者独立从符合条件的试验中提取数据,并与第三位综述作者解决争议。如有需要,我们会联系研究作者索要更多详细信息。我们仅在试验中报告了不良事件时才收集相关数据。 主要结果:我们在本综述中纳入了24项研究,共1250名参与者。这些试验纳入了不同数量和类型的参与者。研究人员使用了一系列方法将液体加热至37°C至41°C之间的温度。我们发现证据质量中等,因为试验设计的描述往往不清晰,由于随机化和盲法程序不当或不清晰,导致偏倚风险高或不明确。这些因素可能在某种程度上影响了结果。我们的方案将低温风险指定为主要结局;由于没有试验报告这一结局,我们决定纳入与平均核心体温相关的数据。试验中报告的唯一可用的次要结局是寒战。关于液体加热对出血的影响,证据不明确。关于我们指定的其他结局,如心血管并发症、感染、压疮、出血、死亡率、住院时间、非计划重症监护病房入院和不良事件,没有报告相关数据。研究人员发现,在30、60、90和120分钟以及手术结束时,加热的静脉输液使研究参与者的核心体温比给予室温静脉输液的参与者高约半度。与室温静脉输液相比,加热后的静脉输液还进一步降低了寒战风险。研究人员报告称,接受加热和室温冲洗液的个体在核心体温或寒战方面没有统计学上的显著差异。 作者结论:加热的静脉输液似乎比室温液体在手术期间能让患者保持更高的体温。目前尚不清楚实际的温度差异在临床上是否有意义,或者使用加热液体是否会带来其他益处或危害。同样不清楚的是,在使用其他加热方法的基础上再使用液体加热是否会带来任何益处,因为当使用多种加热方法时可能会出现天花板效应。

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[8]
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[9]
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[10]
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本文引用的文献

[1]
Intravenous nutrients for preventing inadvertent perioperative hypothermia in adults.

Cochrane Database Syst Rev. 2016-11-22

[2]
Active body surface warming systems for preventing complications caused by inadvertent perioperative hypothermia in adults.

Cochrane Database Syst Rev. 2016-4-21

[3]
Interventions for treating inadvertent postoperative hypothermia.

Cochrane Database Syst Rev. 2014-11-20

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Thermal insulation for preventing inadvertent perioperative hypothermia.

Cochrane Database Syst Rev. 2014-6-4

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Iran J Nurs Midwifery Res. 2014-1

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Rev Lat Am Enfermagem. 2013

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PLoS One. 2012-7-11

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Korean J Anesthesiol. 2012-5-24

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Cochrane Database Syst Rev. 2011-1-19

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Saudi Med J. 2011-1

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