Kuo Chin-Lung, Shiao An-Suey, Yung Matthew, Sakagami Masafumi, Sudhoff Holger, Wang Chih-Hung, Hsu Chyong-Hsin, Lien Chiang-Feng
Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Beitou District, Taipei City 11217, Taiwan ; Institute of Brain Science, National Yang-Ming University, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan ; Department of Otolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan ; Department of Otolaryngology, Taoyuan Armed Forces General Hospital, No. 168, Zhongxing Road, Longtan District, Taoyuan City 32551, Taiwan ; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan.
Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Beitou District, Taipei City 11217, Taiwan ; Department of Otolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Linong Street, Taipei City 11221, Taiwan ; Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 114, Taiwan.
Biomed Res Int. 2015;2015:854024. doi: 10.1155/2015/854024. Epub 2015 Mar 18.
The existence of acquired cholesteatoma has been recognized for more than three centuries; however, the nature of the disorder has yet to be determined. Without timely detection and intervention, cholesteatomas can become dangerously large and invade intratemporal structures, resulting in numerous intra- and extracranial complications. Due to its aggressive growth, invasive nature, and the potentially fatal consequences of intracranial complications, acquired cholesteatoma remains a cause of morbidity and death for those who lack access to advanced medical care. Currently, no viable nonsurgical therapies are available. Developing an effective management strategy for this disorder will require a comprehensive understanding of past progress and recent advances. This paper presents a brief review of background issues related to acquired middle ear cholesteatoma and deals with practical considerations regarding the history and etymology of the disorder. We also consider issues related to the classification, epidemiology, histopathology, clinical presentation, and complications of acquired cholesteatoma and examine current diagnosis and management strategies in detail.
后天性胆脂瘤的存在已被认识超过三个世纪；然而，该疾病的本质尚未确定。如果不及时发现和干预，胆脂瘤可能会变得非常大并侵犯颞内结构，导致许多颅内和颅外并发症。由于其侵袭性生长、浸润性本质以及颅内并发症可能带来的致命后果，后天性胆脂瘤对于那些无法获得先进医疗护理的人来说，仍然是发病和死亡的一个原因。目前，尚无可行的非手术治疗方法。制定针对这种疾病的有效管理策略需要全面了解过去的进展和近期的研究成果。本文简要回顾了与后天性中耳胆脂瘤相关的背景问题，并探讨了有关该疾病历史和词源的实际考量。我们还考虑了与后天性胆脂瘤的分类、流行病学、组织病理学、临床表现和并发症相关的问题，并详细研究了当前的诊断和管理策略。
