Succo Giovanni, Crosetti Erika, Bertolin Andy, Lucioni Marco, Arrigoni Giulia, Panetta Valentina, Sprio Andrea E, Berta Giovanni N, Rizzotto Giuseppe
Otorhinolaryngology Service, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Turin, Italy.
Otorhinolaryngology Service, Martini Hospital, Turin, Italy.
Head Neck. 2016 Apr;38 Suppl 1:E649-57. doi: 10.1002/hed.24064. Epub 2015 Jun 15.
Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique.
We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy.
Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%).
Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension. © 2015 Wiley Periodicals, Inc. Head Neck 38: E649-E657, 2016.
中晚期喉癌在疾病控制和器官保留方面仍然是一项重大挑战。在治疗选择中，开放性部分水平喉切除术被认为是一种保留功能的手术技术。
我们分析了555例pT3至pT4a期喉癌患者接受开放性部分水平喉切除术的临床结果。
5年总生存率（OS）、无病生存率（DFS）、区域控制率、局部控制率、无喉切除术生存率和喉功能保留率分别为84.6%、84.2%、86.3%、90.6%、93.3%和91.2%。DFS、区域控制率和喉功能保留率受pT4a分期的显著影响（分别为68.1%、71.7%和78.0%），而pN+仅影响DFS（≤72.6%）和区域控制率（≤79.6%）。
模块化方法的开放性部分水平喉切除术对于中期和部分晚期喉癌，即使伴有声门下扩展，在预后和功能结果方面可被认为是有效的。©2015威利期刊公司。《头颈》38: E649 - E657, 2016。
